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Toxicological profile for 2,3-benzofuran
This Statement was prepared to give you information about 2,3-benzofuranand to emphasize the human health effects that may result from exposure to it. The Environmental Protection Agency (EPA) has identified 1,177 sites on its National Priorities List (NPL). 2,3-Benzofuran has been found in at least 5of these sites. However, we do not know how many of the 1,177 NPL sites have been evaluated for 2,3-benzofuran. As EPA evaluates more sites, the number of sites at which 2,3-benzofuran is found may change. This information is important for you to know because 2,3-benzofuran may cause harmful health effects and because these sites are potential or actual sources of human exposure to 2,3-benzofuran.
Benzofuran: Production and Applications
Benzofurans have garnered the attention of medicinal chemists due to their broad pharmacological activity. Benzofuran: Production and Applications provides insight into the natural origin of these compounds, reported biological activities for various analogs, synthetic routes to obtain benzofurans substituted at different heterocycle sites, and controlled release encapsulation methods.Dihydrobenzofuran neolignans are secondary metabolites arising from the coupling of two phenylpropanoid units during the shikimate biossynthetic pathway. In this compilation, the natural sources and synthetic routes from which dihydrobenzofuran neolignans can be obtained are reviewed, and their biological potential is highlighted.Additionally, the authors focus on the palladium and rhodium catalyzed multiple C-H functionalizations in the synthesis of benzofurans and their derivatives. The use of Ir and Ru salts is also explored.A review of the aspects related to cancer initiation and progress, as well as the applications of benzofurans as structural frameworks for the development of new drugs against cancer, is provided.
Transition Metal-Catalyzed Benzofuran Synthesis
Transition Metal-Catalyzed Benzofuran Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series provides an overview of benzofuran, describing properties of these heterocycle compounds and the traditional synthetic procedures used for them. The book then explores catalyzed procedures for benzofuran synthesis in greater detail and depth than is currently available in published review articles. This volume is part of the short series authored by Xiao-Feng Wu that summarizes recent achievements on heterocycle synthesis with transition metals as catalysts, with each volume dedicated to one heterocycle compound. Offers a brief, focused review of this active research in benzofuran synthesis via transition metal catalysis Useful coverage of benzofuran properties and both intermolecular and intramolecular cyclization Volume Four in Elsevier’s short work series, Transition Metal-Catalyzed Heterocycles Synthesis Provides greater detail and depth than is currently available in published review articles
Benzofurans, Volume 29
The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
7-Methoxy-2-Phenyl-1-Benzofuran-5-Carbaldehyde
Vanillin undergoes sequence of reaction forming phosphonium salt through dimethyaminomethyl derivative (Mannich reaction). The synthesis of phosphonium salt can be achieved by sequence of three steps which was condense with series of aliphatic/aromatic acid chlorides by refluxing in toluene in presence of triethylamine (Wittig reaction) as key step resulting 7-methoxy-2-phenyl-l-benzofuran-5-carboxaldehyde. The crude product was purified by using column chromatography and characterized by FTIR, NMR and Mass spectroscopy. Computational study of (4) such as Binding energy, density of state, HOMO, LUMO, charge density and reactivity is done by using density functional theory. Based on the results of MTT assay and MB assay, the test compound 04 is shows toxicity against cancerous lung and breast cancer cell lines.
Chlorinated Dioxins and Dibenzofurans in Perspective
This volume was developed from the proceedings of a symposium held in Miami Beach, at the 189th National Meeting of the American Chemical Society.It is the result of the combined efforts of many experts whose efforts have advanced our knowledge of the production, analysis, distribution, effects and control of chlorinated dioxins, dibenzofurans and related compounds.This is the third in a series of publications originating from current technology presented at national meetings of the American Chemical Society. Using this forum as a catalyst, researchers from all over the world came together to present and discuss their data and plan future work in this rapidly developing and sometimes highly emotional technical area.
Polychlorinated Dibenzo-p-dioxins and -furans (PCDDs/PCDFs): Sources and Environmental Impact, Epidemiology, Mechanisms of Action, Health Risks
Polychlorinated Dibenzodioxins and -furans (PCDDs and PCDFs) are potent environmental toxins. Environmental exposures to these compounds in part-per-billion (ppb) and part-per-trillion (ppt) concentrations are of particular interest. These exposures may arise from bleached paper products, paper production process sludge, effluent waste water from paper plants, consumption of food and water from contaminated sources and contact to paper products.
