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Advances in Cancer Research
In this wide-ranging book, one of the boldest thinkers in modern neuroscience confronts an ancient philosophical problem: can we know the world as it really is? Drawing on provocative new findings about the psychophysiology of perception and judgment in both human and nonhuman primates, and also on the cultural history of science, Jean-Pierre Changeux makes a powerful case for the reality of scientific progress and argues that it forms the basis for a coherent and universal theory of human rights. On this view, belief in objective knowledge is not a mere ideological slogan or a naive confusion; it is a characteristic feature of human cognition throughout evolution, and the scientific method its most sophisticated embodiment. Seeking to reconcile science and humanism, Changeux holds that the capacity to recognize truths that are independent of subjective personal experience constitutes the foundation of a human civil society.
Natural history collections have recently acquired an unprecedented place of importance in scientific research. Originally created in the context of systematics and taxonomy, they are now proving to be fundamental for answering various scientific and societal questions that are as significant as they are current. Natural History Collections in the Science of the 21st Century presents a wide range of questions and answers raised by the study of collections. The billions of specimens that have been collected from all around the world over more than two centuries provide us with information that is vital in our quest for knowledge about the Earth, the universe, the diversity of life and the history of humankind. These collections also provide valuable reference points from the past to help us understand the nature and dynamics of global change today. Their physical permanence is the best guarantee we have of a return to data and to information sources in the context of open science.
The intelligence of one is a gift for all. Such is the case of Jérôme Lejeune, an extraordinary man who put his brilliance at the service of children with Down syndrome. A pioneer of modern genetics, Dr. Lejeune discovered the chromosomal defect that causes Down''s. International acclaim followed, but more important to this doctor—dazzled by the beauty of every human life—was improving the care of his patients with this abnormality. As a man of both science and conscience, he advocated for their dignity, and he suffered attacks on his reputation as a result. To write this definitive biography, Aude Dugast spent eleven years consulting thousands of archives. She met at length with Lejeune''s wife and relatives, families of his patients, and his French and foreign collaborators. She invites us to discover the true and untold portrait of Jérôme Lejeune—brilliant scientist close to the great figures of this world, devoted husband and father, and ardent defender of the little ones.
Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization (FISH) and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic seque...
Publisher Description
Chromosomes Today, Volume 13 includes the plenary lectures presented at the 13th International Chromosome Conference, covering the most recent advances in the studies on chromosomes. The contributions in this volume were presented by some of the world's leaders in cytogenetic and molecular research and outline the present status of knowledge on the composition, structure, function and evolution of chromosomes, including, among others, the advancement of the human genome project. The use of cytogenetic studies has greatly increased in the last few years, resulting in a progressive improvement in the available methods that has consequently allowed a more detailed analysis of the molecular organization of eukaryotic chromosomes and a precise in situ localisation of specific gene sequences. This volume of Chromosomes Today provides up-to-date information regarding the topics at the forefront of chromosome research: genetic regulation, imprinting, DNA duplication, meiotic pairing, and the regulation of the...