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Radiation Oncology: An Evidence-Based Approach (ROEBA) is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions on the basis of the best available scientific evidence. Ease of use is ensured by a structured, reader-friendly format that offers rapid access to evidence-based recommendations. ROEBA’s orientation is entirely practical, in that the focus is solely on diagnostic/staging and treatment issues. Detailed diagnostic and therapeutic guidelines are provided for multidisciplinary cancer management as well as radiation therapy techniques. The evidence underlying each recommendation is clearly and concisely explained, and the strength of the recommendations and evidence is systemically graded. Furthermore, diagnostic and treatment algorithms are provided for the commonly diagnosed cancers. This ground-breaking text on radiation oncology is an essential tool for physicians in their daily clinical practice.
Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Decision Making in Radiation Oncology is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions effectively and efficiently. The design is based on the belief that “a picture is worth a thousand words.” Knowledge is conveyed through an illustrative approach using algorithms, schemas, graphics, and tables. Detailed guidelines are provided for multidisciplinary cancer management and radiation therapy techniques. In addition to the attention-riveting algorithms for diagnosis and treatment, strategies for the management of disease at individual stages are detailed for all the commonly diagnosed malignancies. Clinical trials that have yielded “gold standard” treatment and their results are documented in the schemas. Moreover, radiation techniques, including treatment planning and delivery, are presented in an illustrative way. This groundbreaking publication is an essential tool for physicians in their daily clinical practice.
The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 100 papers included in the second volume have been organized in the following topical sections: biophysical modeling and simulation; atlas-based transfer of boundary conditions for biomechanical simulation; temporal and motion modeling; computer-aided diagnosis; pediatric imaging; endoscopy; ultrasound imaging; machine learning; cardiovascular imaging; intervention planning and guidance; and brain.
The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. - Provides in-depth description of targeted systems and treatment strategies - Explains the underlying cancer biology necessary for understanding a given therapeutic approach - Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses - Presents translational focus with emphasis on requirements for clinical implementation - Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference
Here is an exciting new guide to the use of PET-CT imaging in radiotherapy. You’ll get practical, useful information for utilizing this novel imaging technique—from different methods for contouring biological target volumes in various anatomic regions to how different experts use this imaging in targeted treatment. This thorough text helps you make concise, accurate treatment choices based on current evidence and expert authority. The result is an essential tool for everyone on the radiotherapy treatment team in the era of image-guided radiotherapy. Helps familiarize you with the basics of PET imaging in nuclear medicine. Covers the use of PET-CT with radiotherapy treatment planning, offering practical guidance in how different experts use this relatively new technology. Highlights contrast using full-color images, clearly indicating target volumes and different radiation dosages. Outlines the advantages and disadvantages of different techniques in contouring PET-CT target volumes for radiotherapy. Features case illustrations in using PET-CT in radiotherapy treatment planning for different tumor sites.
A burnt-out exobiologist and a peaceful space hauler have their lives changed forever by an irresistible proposition—one that may send everyone hurtling toward annihilation. Chaeyoung No has devoted her career to disproving a theory that abiotic oxygen sterilized the cosmos. A weapons manufacturer has just offered to fund her dreams. She could silence her critics forever, but can she trust her funders? Frederik Obialo yearns to build a permanent home for his daughter. When he’s offered triple pay for a quick haul, he sees his chance. All he has to do is shuttle some people to a weather station and ignore all the warning signs. Their choices have sunk them deep into the shadowy world of corporate espionage. Now they have to deal with black ops kill teams, and military intrigue. But an alien discovery shatters their understanding of the universe. As they reveal eons-hidden truths, Chaeyoung and Frederik will propel humanity away from the path of the pale blue dot...toward the singularity of A Mote in Shadow.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.