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The Everything Guide
Feel your best — for the rest of your life. The essential new book from bestselling health writer and trusted menopause advocate Niki Bezzant, author of This Changes Everything. In The Everything Guide, Niki brings together her decades of research and writing about food, exercise and personal health with the very latest, evidence-based expert advice in an informative, practical, easy-to-read (and always honest!) must-have manual for every woman in midlife and beyond. Niki re-frames ageing for a new generation, tackling body image struggles; mental health challenges; feeling ‘lost’ in midlife and re-connecting with ourselves during a time of hormonal transition. The book is also packed ...
Pembrim
There had been whispers of a magical hidden alcove within the Fenix Forest of Ameral Alley for years, but according to legend, no one had ever found it. Until now. Seventeen-year-old Halia Bodine, a girl with a medically baffling rare lung disease, begins dreaming of a map that leads her to the hidden alcove of Moa's Rock. In the depths of this magical alcove exists the vibrant underwater world of M'deia, with its hunter tribes, alluring creatures, ghastly beasts, and untouched lands. After a fated encounter with Luka, a M'deian boy in exile from his clan, Halia enters this mythical underwater world. Once there, she learns that her illness ceases to exist, that she loves without reciprocatio...
Honte
« Il existe des hontes qu’il est de bon ton d’avoir. J’ai appris à m’en débarrasser. Il existe des hontes universelles qui nous confortent dans notre appartenance au genre humain. Il existe des hontes que l’on traverse, et d’autres qui nous empêchent. Il existe des hontes plus ou moins puissantes, des hontes furtives et des hontes qui s’ancrent. Il existe des hontes si terribles. Des hontes qui foudroient. Et il existe des hontes qui font partie de nos vies simplement parce que nous sommes nées filles. »
New Trends in Cancer for the 21st Century
This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view.
The Oncogenomics Handbook
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Pharmacokinetics and Pharmacodynamics of Biotech Drugs
This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
Major Companies of The Far East and Australasia 1991/92
This book represents the eighth edition of what has become an established reference work, MAJOR COMPANIES OF THE Guide to the FAR EAST & AUSTRALASIA. This volume has been carefully researched and updated since publication of the previous arrangement of the book edition, and provides more company data on the most important companies in the region. The information in the This book has been arranged in order to allow the reader to book was submitted mostly by the companies themselves, find any entry rapidly and accurately. completely free of charge. For the second time, a third volume has been added to the series, covering major companies in Company entries are listed alphabetically within each...
Feline Orthopaedics
Cats are not referred to specialists as frequently as dogs, meaning the general practitioner must routinely treat cats that have been involved in road traffic accidents and other musculoskeletal trauma. This book is the first of its kind to provide a practical and user-friendly guide to feline orthopaedics. With a new author team, led by RCVS Specialist in Small Animal Surgery (Orthopaedics) and Veterinary Neurology Harry Scott, the second edition has been thoroughly revised and updated. New chapters cover Physiotherapy and Oncology of the Feline Skeletal System. The book includes highly structured fully referenced text that provides a concise, straightforward guide to the recognition and ma...
The City Record
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Forestry in Ireland
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