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APC Proteins
The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc protein.
Hot Topics in Infection and Immunity in Children VI
Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections. Each of the chapters in this book is based on a lecture given at the sixth "Infection and Immunity in Children" course, held at the end of June 2008 at Keble College, Oxford. Thus, it is the sixth book in a series that provides succinct and readable updates on just about every aspect of the discipline of Pediatric Infectious Diseases.
Paraoxonases in Inflammation, Infection, and Toxicology
The pivotal role of the Paraoxonases (PON) family in a variety of inflammatory diseases, e.g. atherosclerosis, in preventing the toxicity of organophosphorus insecticides and nerve agents and a variety of other compounds has made them an interesting target for both clinicians and scientists alike. Research into the paraoxonase (PON) family of enzymes (PON1, PON2 and PON3) has increased exponentially over the last five years especially following the initiation of paraoxonase conferences.The objectives of the 3rd ICP remains the same as the previous two conferences: to disseminate the latest aspects of research into the genetics, biochemistry, structural biology, regulation of PONs and their r...
Osteoimmunology
It has only recently been appreciated that the immune and skeletal systems have major interactions. It is now well documented that osteoclasts, which are important cellular mediators of skeletal homeostasis, are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines that were first shown to regulate immune cell function have also been demonstrated to regulate bone cells and influence skeletal health. Conversely, products of bone cells appear critical for the engraftment of marrow in bone, the normal development of the hematopoietic and immune systems and provide niche for long-term memory B and T cells. In the past scientists involved in im...
Between the Devil and the Deep
'One of the best accounts ever written of deep-water diving and its staggering, haunting dangers' Robert Kurson, New York Times bestselling author of Shadow Divers Deep underwater lurks a mysterious man-made illness. It has gone by many names over the years – Satan’s disease, diver’s palsy, the chokes – but today, medics call it decompression sickness. You know it as the bends. That’s the devil British diver Martin Robson faces each time he plunges beneath the surface. In the winter of 2012, Robson was part of an expedition to Blue Lake, southern Russia, which sought to find a submerged cave system never seen by the human eye. On the final day of the expedition, as Robson returned ...
Brat
Fans of Patti Smith's Just Kids and Rob Lowe's Stories I Only Tell My Friends will love this beautifully written, entertaining, and emotionally honest memoir by an actor, director, and author who found his start as an 80s Brat pack member -- the inspiration for the Hulu documentary Brats, written and directed by Andrew McCarthy. Most people know Andrew McCarthy from his movie roles in Pretty in Pink, St. Elmo's Fire, Weekend at Bernie's, and Less than Zero, and as a charter member of Hollywood's Brat Pack. That iconic group of ingenues and heartthrobs included Rob Lowe, Molly Ringwald, Emilio Estevez, and Demi Moore, and has come to represent both a genre of film and an era of pop culture. I...
Missing Microbes
A critical call to arms about the harmful effects of some of our most revered modern medical practices. Welcome to the wilds of the microbiome, where for hundreds of thousands of years bacterial and human cells have co-existed in a peaceful symbiosis that is responsible for the equilibrium and health of our bodies. But now this invisible Eden is under assault. Our overreliance on medical advances such as antibiotics and Cesarean sections is threatening the extinction of these irreplaceable microbes and leading to severe health problems. In Missing Microbes, Dr. Martin Blaser goes back to the discovery of antibiotics, which ushered in a golden age of medicine, and traces how our subsequent ov...
It Had to be Tough
This book tells the fascinating story of the origins of the Commandos (Britain's first Special Service troops and the forerunners of today's Parachute Regiment, the SAS and the SBS) and the development of their special training in World War II. The commandos were raised on the specific and personal orders of the prime minister, Winston Churchill, in the dark days of the summer of 1940 when these islands faced the real threat of a Nazi invasion. It was a bold, but typically Churchillian, decision.The book traces the formation of the Commandos and the development of the extreme and often unorthodox training methods and techniques used to prepare the volunteers from all branches of the British ...
