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Clinical Trials in Older Adults is the first book to consider the methodological issues underlying the evaluation of new treatments in older people. Provides information on the methodology, monitoring and regulations for those planning to conduct a clinical trials involving older adults Contains examples of ongoing trials involving older adults, and presents the main characteristics of many recently published Depicts how the issues regarding older adults in clinical trials could be properly addressed with the appropriate study design and conduct Identifies key issues in performing clinical trials in older patients with common geriatric conditions, i.e. Alzheimer’s dementia, depression, low muscle mass, cancer
This new edition of the comprehensive and renowned textbook Principles and Practice of Geriatric Medicine offers a fully revised and updated review of geriatric medicine. It covers the full spectrum of the subject, features 41 new chapters, and provides up-to-date, evidence-based, and practical information about the varied medical problems of ageing citizens. The three editors, from UK, USA and France, have ensured that updated chapters provide a global perspective of geriatric medicine, as well as reflect the changes in treatment options and medical conditions which have emerged since publication of the 4th edition in 2006. The book includes expanded sections on acute stroke, dementia, card...
This book is the first of a new series which will present the proceedings of the newly established Nestlé Nutrition Workshop Series: Clinical & Performance Programme aimed at adult nutrition. Undernutrition is a common phenomenon in elderly people, and malnutrition reaches significant levels in those being in hospital, nursing homes or home care programs. Consequences of malnutrition often go unrecognised owing to the lack of specific validated instruments to assess nutritional status in frail elderly persons. The Mini Nutritional Assessment (MNA) provides a single, rapid assessment of nutritional status in the elderly of different degrees of independence, allowing the prevalence of protein...
Current Topics in Breast Cancer Survivorship is an important collection of essays about the health and wellbeing of breast cancer survivors. The audience for the book includes graduate students, health professionals and researchers from many different disciplines, including epidemiology, behavioral science, medicine, oncology, nursing, and health disparities. This book will likely be of interest to health professionals and researchers from various disciplines and members of non-profit organizations, government agencies, and health advocacy organizations. The book is organized into six key sections. The first section provides information about comorbid conditions such as cardiovascular diseas...
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The demographic shift in the average age of the population worldwide calls for careful attention to the nutritional and health needs of the elderly. Frailty has been associated with increased disability, postsurgical complications and increased mortality; in a frail state, older adults are at greater risk for adverse outcomes, including falls and admissions to hospital and nursing homes. Despite the strong associations between frailty and subsequent poor outcomes, limited attention to this common geriatric condition has been paid in clinical settings. Emerging evidence suggests that both behavioral (nutrition and physical activity) and pharmacologic interventions may be effective in the treatment and prevention of the frailty syndrome. The papers in this book address our current understanding of the biological basis, clinical presentation and therapeutic interventions that target frailty. They highlight the transitional nature of research on the frailty syndrome and identified key unmet needs and areas for future investigation in this expanding field.
"Three chief evils that hang over us are disease, old age, and death. To study and control senescence, Metchnikoff proposed the establishment of a new scientific discipline he named 'gerontology.' In this classic text on the prolongation of life, Metchnikoff suggests that science should be encouraged and helped in every possible way in its task of removing the diseases and habits that now prevent human life from running its normal course, and his belief is that, were the task accomplished, the great cause of pessimism would disappear. Metchnikoff was able to proclaim himself an optimist, and found, in biological science, for the present generation a hope, or at the least an end towards which to work, and for future generations a possible achievement of that hope." ó From the Introduction by Gerald Gruman, MD, PhD
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