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Implementation of the Small-Scale Fisheries Guidelines
Zusammenfassung: Since the landmark endorsement of the Voluntary Guidelines for Securing Sustainable Small-Scale Fisheries in the Context of Food Security and Poverty Eradication (SSF Guidelines) in 2014 by the Committee on Fisheries of the Food and Agriculture Organization of the United Nations (FAO), governments and a wide-range of stakeholders, including the Too Big To Ignore (TBTI) Global Partnership for Small-Scale Fisheries, have been working towards an effective and adequate implementation of the Guidelines. Now a decade later, it is time to take stock of how the SSF Guidelines have been integrated into fisheries governance at the national level around the world. This book is a contri...
GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
Insights into Receptor Function and New Drug Development Targets
This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
Materials Selection for Sustainability in the Built Environment
Materials Selection for Sustainability in the Built Environment: Environmental, Social and Economic Aspects presents the current state-of-the-art when it comes to the decision-making process for choosing construction materials to deliver sustainable construction projects. Aspects covered include the science of enhanced decision-making via operational research and machine learning techniques and how this can be implemented in various disciplines such as architecture, engineering and construction. To this end, the book discusses environmental, economic and social aspects in assessing construction materials and presents different tools and methods that can benefit and facilitate this process. F...
Wildlife DNA Analysis
Clearly structured throughout, the introduction highlights the different types of crime where these techniques are regularly used. This chapter includes a discussion as to who performs forensic wildlife examinations, the standardisation and validation of methods, and the role of the expert witness in this type of alleged crime. This is followed by a detailed section on the science behind DNA typing including the problems in isolating DNA from trace material and subsequent genetic analysis are also covered. The book then undertakes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons. A comparison of the different markers used in species ...
The Geology of Spain
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