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Practical Endocrinology and Diabetes in Children
The practical manual for pediatricians andendocrinologists Practical Endocrinology and Diabetes in Children, SecondEdition, continues to provide a very practical overview of managingendocrine problems in children. Coverage of each disorder reflectsits clinical importance. The material is organized in such a waythat it can be referred to at a moment's notice. Helpful overviewsof epidemiology, pathophysiology, investigations, differentialdiagnoses and psychosocial issues support the advice on managementprinciples. New features of this Second Edition include: Completely revised first chapter on diabetes Additional growth charts added to the appendix New Editor, Raymond L. Hintz, MD, Stanford University MedicalCenter, joins the team and brings a North American perspective tothe text New section added to each chapter entitled ‘Potentialpitfalls’ to help you avoid common problems
Practical Endocrinology and Diabetes in Children
The revised and updated fourth edition of Practical Endocrinology and Diabetes in Children offers a practical, highly clinical and up-to-date handbook of paediatric endocrinology and diabetes. The book is written in clear terms and offers a user-friendly format that is designed to be concise, yet comprehensive.. The international panel of expert contributors explore the range of endocrine disorders in children including growth, thyroid, adrenal and problems related to puberty.
Current Indications for Growth Hormone Therapy
Growth hormone (GH) has been used therapeutically for over 50 years. Since the development of a nearly unlimited supply of recombinant human GH in the mid-1980s, children with less severe GH deficiency can also profit from GH replacement therapy. Careful and accurate diagnosis and specific dosing, both essential to ensure normal height development, require the clinician to understand the finer points of clinical trials, to acquire quality evidence and assess the benefits of therapeutic intervention. Furthermore, genetic and environmental factors influencing GH sensitivity and responsiveness need to be taken into account. In this second edition all these aspects are covered in depth. Clinical examination, detailed auxological measurements, bone age assessment, molecular analysis and neuro-radiological evaluation as well as an adaptive strategy of dosing focusing on a patient's individual responsiveness are discussed in detail. This volume of Endocrine Development is essential reading for pediatric endocrinologists, pediatricians and clinical nurse specialists involved in GH therapy.
Puberty from Bench to Clinic
Puberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact of environmental factors in relation to critical periods in development. Not only showing the consensus and controversial issues in the v...
Childhood and Adolescent Diabetes
Written by individuals who between them currently share in the care of over 1,000 young diabetics, the book provides answers to the questions asked by parents and practical solutions to the problems confronting children, young people and their parents. In addition, suggestions and solutions are provided for professionals who are developing packages of care, audit systems, standards and activities outside the diabetic clinic. Special attention is given to the role of the paediatric diabetes nurse specialist and the purpose of the children's diabetic clinic, with particular strategies of care and examples of documentation being provided.
Male Hypogonadism
Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next ar...
Diagnostics of Endocrine Function in Children and Adolescents
A multitude of new developments, not only in the rapidly advancing field of molecular genetics and steroid metabolism but in all traditional areas of pediatric endocrinology, have influenced the diagnostic approach in children and adolescents with endocrine disorders, thus warranting this 4th, revised and extended edition of 'Diagnostics of Endocrine Function in Children and Adolescents'. Several chapters have been revised completely and all have been thoroughly updated. In addition, new chapters dealing with the muscle-bone unit and bone metabolism have also been incorporated. The original format of the chapters, which are a combination of in-depth discussion of the diagnostic process, prac...
Handbook of Neuroendocrinology
Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are triggered and/or controlled by neuroendocrine systems. In turn, neuroendocrine dysfunction due to g...
The Developing Testis
The Developing Testis' is a complex site of various differentiation events resulting in two main functions in adult life - gametogenesis and androgen biosynthesis. Testis research is multidisciplinary in its nature and attracts both basic and clinical scientists. The purpose of this volume has therefore been to bring together a group of expert scientists in the fields of physiology, endocrinology, pediatrics and andrology to sum up our current knowledge on human testicular development, from the state of male sex determination to the end of puberty. The contents span from molecular events in male sex determination and testis differentiation to clinical entities such as the testis in childhood...
Late Effects of Childhood Cancer
The treatment of childhood cancer has become increasingly successful over the last forty years, and during the last two decades in particular, and the overall cure rate is now 60-70%. This, in turn, has introduced new issues for the clinician as the number of long-term survivors has increased. Some of the therapies that have contributed most to the
