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Cystic Fibrosis has seen dramatic advances in treatment since the last edition, including targeted cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators for most CFTR gene abnormalities. This new fifth edition is an update and expansion of the rapid clinical and scientific advances in improving prognosis, and the impact of COVID-19, all of which has transformed conventional models of care. It covers basic science, such as how detailed understanding of the biology of the CFTR gene and protein has led to novel and beneficial therapies, as well as all aspects of clinical management in high-, middle- and low-income settings and the voices of individuals with CF from acros...
Written to commemorate 30 years since the United Nations Convention on the Rights of the Child (UNCRC), The Routledge International Handbook of Young Children’s Rights reflects upon the status of children aged 0–8 years around the world, whether they are respected or neglected, and how we may move forward. With contributions from international experts and emerging authorities on children’s rights, Murray, Blue Swadener and Smith have produced this highly significant textbook on young children’s rights globally. Containing sections on policy, along with rights to protection, provision and participation for young children, this book combines discussions of children’s rights and early...
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Immunologie is de studie van het immuunsysteem. Het immuunsysteem is uitermate dynamisch en ingewikkeld en heeft als belangrijkste doel het lichaam te beschermen tegen infecties door alle mogelijke micro-organismen en parasieten. Veel verschillende celtypen en moleculen werken samen om zo'n infectie te bestrijden. Het immuunsysteem is altijd actief, gelukkig veelal zonder dat we het merken. Immunologie is een modern vakgebied dat volop in beweging is. Veel ziekten en aandoeningen hebben een immunologische component en tal van nieuwe therapieën zijn gestoeld op immunologische werkingsprincipes.In Immunologie wordt het complexe immuunsysteem van de mens helder en overzichtelijk uiteengezet. I...
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This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.