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Sepsis, Kidney and Multiple Organ Dysfunction
Severe sepsis is among the most common causes of death in the United States and the most common cause of death in the Intensive Care Units worldwide, and its recognition and treatment remain the most important challenges of critical care medicine. Severe sepsis and septic shock have a profound effect on kidney function and the function of other organs through complex mechanisms, which involve the immune response, multiple pro and anti-inflammatory pathways, intracellular dysfunction and hemodynamic instability. Their optimal management requires complex knowledge of general medicine, immunology, nephrology, extra-corporeal technology, fluid resuscitation and critical care endocrinology. In or...
Acute Kidney Injury
Acute kidney injury is defined as an abrupt change in serum creatinine and/or urine output, and a majority of patients admitted to the ICU have some evidence of the disorder. Unfortunately, treatment for this complex syndrome is as yet lacking and understanding is limited. An interdisciplinary panel of experts has contributed to this volume, illuminating some of the fundamental and complex aspects of the disorder ranging from pathophysiology to treatment, from emerging biomarkers to genetic polymorphisms. Other contributions focus on immunological issues or the many complications of acute kidney injury and co-morbid conditions encountered, covering the fundamentals as well as the latest deve...
Blood Purification in Intensive Care
In the last twenty years, critical care medicine has been established as a specialty with its own therapies and procedures, with significant implications for clinical nephrology regarding severe acute renal failure. This typically multi-factorial condition is today predominantly seen in intensive care units. The complex knowledge and skills necessary to handle it have resulted in a field called Critical Care Nephrology, where nephrologist and intensivist either work side by side or have formally acquired expertise and training in both specialties. Extracorporeal renal replacement therapies, although originally used to treat end-stage renal disease patients, rapidly gained importance for acut...
Platelet-Activating Factor and Related Lipid Mediators
Platelet-activating factor (PAF) is the commonly used name for a group of potent biologically active, ether-linked phospholipids, the alkylacetylglycerophospho cholines. Following the identification of the chemical structure of P AF in 1979, much progress has been made in our understanding of these phospholipid medi ators. This is particularly true from the points of view of their molecular structural requirements for expression of biological activity, their biosynthesis and cata bolism, their diverse range of biological activities, evidence for their specific recep tors at the cell surface, the development of specific antagonists for use in receptor studies and for testing as potential anti...
Critical Care Nephrology E-Book
Comprehensive and clinically relevant, the 3rd Edition of Critical Care Nephrology provides authoritative coverage of the latest advances in critical care procedures for patients with renal diseases or disorders. Using common guidelines and standardized approaches to critically ill patients, this multidisciplinary reference facilitates better communication among all physicians who care for critically ill patients suffering from kidney disease, electrolyte and metabolic imbalances, poisoning, severe sepsis, major organ dysfunction, and other pathological events. - Offers detailed discussions of different forms of organ support, artificial organs, infections, acute illness occurring in chronic...
Advances in Hemostasis and Thrombosis
A greater knowledge of the basic molecular mechanisms which regulate platelet function, coagulation, the fibrinolytic system and their interaction with the vessel wall has allowed a better understanding of the numerous aspects involved in the pathogenesis of thrombosis and the regulation of hemostasis. Thrombosis represents today one of the causes of death in the Western hemisphere. Arterial thrombosis may lead to myocardial infarction, cerebral and peripheral vascular diseases. Venous thrombosis, on the other hand, is a complication of heart disease, surgery, extensive trauma, several obstetric pathologies, and may, at times, develop in apparently healthy subjects. These complex problems are dealt with within the content of "Advances in Hemostasis and Thrombosis." The present papers contain up-to-date information on hemostasis, the role of prostaglandins, fibrinolytic coagulation, rheology, and modern therapeutic approaches along with their clinical application. This book, therefore, offers the reader the opportunity to profit from a rare encounter, an interdisciplinary cooperation, with scientific contributions from numerous countries.
Yearbook of Intensive Care and Emergency Medicine
The Yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Continuous Renal Replacement Therapy
In the past decade, CRRT has moved from a niche therapy within specific specialty centers to the standard of care for management of critically ill patients with acute renal failure. Continuous Renal Replacement Therapy provides concise, evidence-based, to-the-point bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on Theory; Pratice; Special Situations; and Organizational Issues, Continuous Renal Replacement Therapy provides a complete view of CRRT theory and practice. Generous tables summarize and highlight key points, and key studies and trials are listed in each chapter.
Replacement of Renal Function by Dialysis
The leading Textbook on the subject. A completely rewritten and up-to-date fifth edition, based upon the highly respected fourth edition, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch and J.F. Winchester. This new edition is truly global in scope and features the contributions of the top experts from around the world.
