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Methods in Cancer Stem Cell Biology
  • Language: en
  • Pages: 251

Methods in Cancer Stem Cell Biology

This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters of this...

Desperate Hours
  • Language: en
  • Pages: 293

Desperate Hours

"A stupendous feat of reportage." -Ron Powers, cowriter of Flags of Our Fathers Praise for Desperate Hours "Goldstein's book is packed with detail. . . . This description of the Doria's sinking is especially moving." -The New York Times "A stupendous feat of reportage. Goldstein has virtually put us into lifeboats and sent us hurtling into the North Atlantic on the night of July 25, 1956." -Ron Powers, cowriter, Flags of Our Fathers, and author of Dangerous Water and Tom and Huck Don't Live Here Anymore On an extraordinary summer's night in 1956, in a fog off Nantucket, the world-renowned ocean liner Andrea Doria collided with the Swedish liner Stockholm and, eleven hours later, tragically s...

Topological Data Analysis for Genomics and Evolution
  • Language: en
  • Pages: 522

Topological Data Analysis for Genomics and Evolution

Biology has entered the age of Big Data. A technical revolution has transformed the field, and extracting meaningful information from large biological data sets is now a central methodological challenge. Algebraic topology is a well-established branch of pure mathematics that studies qualitative descriptors of the shape of geometric objects. It aims to reduce comparisons of shape to a comparison of algebraic invariants, such as numbers, which are typically easier to work with. Topological data analysis is a rapidly developing subfield that leverages the tools of algebraic topology to provide robust multiscale analysis of data sets. This book introduces the central ideas and techniques of topological data analysis and its specific applications to biology, including the evolution of viruses, bacteria and humans, genomics of cancer, and single cell characterization of developmental processes. Bridging two disciplines, the book is for researchers and graduate students in genomics and evolutionary biology as well as mathematicians interested in applied topology.

What tumors teach us
  • Language: en
  • Pages: 353

What tumors teach us

Lze se pro dobré fungování lidské společnosti poučit nebo inspirovat studiem nádorů? Jak vznikají? Proč nás tolik zajímají? Co nás učí? Mnohobuněčný organismus je v této knize prezentován jako komplexní systém tvořený mnoha buňkami, které spolupracují, zatímco nádory jsou důsledkem opuštění spolupráce a porušování jejích základních principů. Autorka na základě obecné teorie systémů hledá paralely a extrapolace pravidel spolupráce a forem jejich porušování i v jiných komplexních systémech, včetně lidské společnosti. Vedle detailnějšího vhledu do podstaty vzniku a vývoje nádorů kniha nabízí zamyšlení nad otázkou, zda i lidé, podobně jako nádorové buňky, neporušují nebezpečně a sebedestruktivně klíčová pravidla podmiňující dobré fungování systému, jehož jsou součástí.

Cancer Targeted Drug Delivery
  • Language: en
  • Pages: 717

Cancer Targeted Drug Delivery

This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal ...

Chemically-Induced DNA Damage, Mutagenesis, and Cancer
  • Language: en
  • Pages: 275

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

  • Type: Book
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  • Published: 2018-08-27
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  • Publisher: MDPI

This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

Stalin’s Drive to the West, 1938-1945
  • Language: en
  • Pages: 424

Stalin’s Drive to the West, 1938-1945

Exploiting new findings from former East Bloc archives and from long-ignored Western sources, this book presents a wholly new picture of the coming of World War II, Allied wartime diplomacy, and the origins of the Cold War. The author reveals that the story - widely believed by historians and Western wartime leaders alike - that Stalin's purposes in European diplomacy from 1938 on were mainly defensive is a fantasy. Indeed, this is one of the longest enduring products of Stalin's propaganda, of long-term political control of archival materials, and of the gullibility of Western observers. The author argues that Stalin had concocted a plan for bringing about a general European war well before...

Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications
  • Language: en
  • Pages: 619

Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications

  • Type: Book
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  • Published: 2012-11-30
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  • Publisher: IGI Global

"This book translates basic science discoveries into regenerative therapies with the application of clinical tool in aging and tissue regeneration"--

Swedish Volunteers in the Russo-Finnish Winter War, 1939-1940
  • Language: en
  • Pages: 261

Swedish Volunteers in the Russo-Finnish Winter War, 1939-1940

  • Type: Book
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  • Published: 2014-01-10
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  • Publisher: McFarland

Sandwiched between Nazi Germany and the "Russian Bear," Sweden walked a diplomatic tightrope on if and how it should support Finland during the Russo-Finnish Winter War. Social and political forces motivated the Swedish leadership to promote neutrality and avoid official military engagement, while at the same time the Swedish Volunteer Corps comprised the largest volunteer combat force (more than 8,200 strong) in any modern war. This book discusses the political background of the 1939-1940 Winter War; setbacks the volunteers suffered due to weather and terrain; and the ever-present fear that war would come to the Scandinavian Peninsula.

The Journal of Historical Review
  • Language: en
  • Pages: 408

The Journal of Historical Review

  • Type: Book
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  • Published: 2000
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  • Publisher: Unknown

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