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New Concepts in Stroke Diagnosis and Therapy
This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune system, genetic factors and the neurovegetative system, to the role of new imaging techniques in improving diagnosis and treatment, from preventive therapy and recanalization to the important and intriguing effects of neuroprotection, neuroregeneration and post stroke rehabilitation. Readers will be able to understand perspectives from stroke medicine researchers about the relationship between the nervous system and other physiological systems in the body and their role in the onset and treatment of stroke. The volume is intended as a resource for neurologists and medical professionals involved in other specialties such as cardiology, internal medicine, rehabilitation and physiology.
Excitotoxicity in Neurological Diseases
It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die i...
Environmental Stressors and OxInflammatory Tissues Responses
Environmental risk factors – noise, air pollution, chemical agents, and ultraviolet radiation – impact human health by contributing to the onset and progression of noncommunicable diseases. Accordingly, there is need for preclinical and clinical studies and comprehensive summary of major findings. This book is a state-of-the-art summary of these myriad severe life stressors. The chapters on the different pollutants focus on disease mechanisms (cardiovascular, neurological and metabolic disorders) and on oxidative stress and inflammation. The editors emphasize emerging mechanisms based on dysregulation of the circadian clock, the microbiome, epigenetic pathways, and cognitive function by environmental stressors, and introduce the exposome concept while highlighting existing research gaps. Key Features: Links various environmental stressors to the incidence of noncommunicable diseases Includes chapters on airborne toxins, chemical pollutants, noise, and ultraviolet radiation stressors Contributions from an international team of leading researchers Summarizes the impacts of stressors on disease mechanisms
Scientific Directory and Annual Bibliography
Each issue lists papers published during the preceding year.
Neurodegenerative Diseases
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Prognosis of Neurological Diseases
This book offers clear, detailed guidance on all aspects of prognostic evaluation in patients who have been involved in a serious accident with neurological consequences or have been diagnosed with a severe neurological illness. It covers the full range of disorders of the central and the peripheral nervous system, not only providing very accurate prognostic estimates but also addressing relevant clinical issues, differential diagnosis, and the role of imaging. The book is practically oriented and designed for use on a daily basis when assessing prognosis and discussing the outcome with patients, their families, and other interested parties. It will support patient–doctor partnerships by ensuring that the most professional answers can be given to patients' and doctors' questions and by promoting realistic expectations of the effect of medical interventions. In addition, it will enable doctors, lawyers, and other professionals to understand relevant issues when an estimate of prognosis and life expectancy is the subject of legal dispute.
The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances...
Toxicity and Autophagy in Neurodegenerative Disorders
Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
The Role of Neurotransmitters in Brain Injury
Neuroscientists from various disciplines have given extraordinary attention to the role of neurotransmitters in the field of neuronal injury. This volume summarizes the original oral and poster contributions which were presented at the symposium, "The Role of Neurotransmitters in Brain Injury," in Key West, Florida, between June 7-9, 1991. This symposium was the official Satellite of Brain-91, the Fifteenth International Symposium on Cerebral Blood Flow and Metabolism, held in Miami the previous week. The two principal goals of the Key West satellite meeting were to document recent progress and, more importantly, to explore future directions for investigative studies of the role of neurotran...
