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International Review of Neurobiology
Volume 42 presents an in-depth review on Alzheimer's Disease as well as a look at several transcription factors. - Clinical features of stroke and the current stasis of stroke therapy - Alzheimers Disease--pathology, pathological proteins, etiology, pathogenesis, neurotransmitter alterations, and treatment strategies - An examination of the regulation of AP-1 and related transcription factors and their role in brain injury and drug abuse-related behavior - Emerging roles of the transcription factor NF(B - Recent advances about the nature of alterations in ion channel structure or function which may be responsible for epileptogenesis - An integrated model accounting for the multiple mechanisms involved in the posttranslational regulation of glutamate ionotroic receptors - Genetic mutation and the Glycine Receptor
Central Nervous System Trauma
Central nervous system trauma, which encompasses stroke, subarachnoid hemorrhage, head injury, and spinal cord injury, is a leading cause of death in developed countries. In the search for underlying mechanisms, membrane involvement has been the common link. This fourth volume in the Membrane-Linked Diseases series is therefore dedicated to research on CNS trauma. Focusing on the mechanism of membrane damage, Central Nervous System Trauma: Research Techniques presents a variety of experimental techniques to study the mechanism of CNS trauma. Animal and tissue culture models provide the bulk of the research findings in this area. Possible pharmacological interventions are analyzed. This volume offers numerous illustrative examples, including full color figures. This book serves as a valuable resource for students and researchers, assisting in the comprehension of current trends in CNS trauma and helping to stimulate the discovery of new research areas.
Neurobiology of Ischemic Brain Damage
In the eight years since the publication of Volume 63 of Progress in Brain Research, on this subject, developments in the research field have been very fast. For example, receptor physiology and pharmacology is now an intensively studied field, and the excitotoxic hypothesis of cell death is commonly accepted. Furthermore, it is recognized that ischemia and other insults give rise to a sustained depression of overall protein synthesis, yet lead to the expression of dormant genes and to synthesis of new proteins.In view of this development, this volume focusses on the cellular and molecular aspects of ischemic brain damage. The book will be of great value to all those interested in the pathophysiology of ischemic and traumatic brain damage.
Recovery After Traumatic Brain Injury
Emotions, behaviors, thoughts, creations, planning, daily physical activities, and routines are programmed within our brains. To acquire these capacities, the brain takes time to fully develop--a process that may take the first 20 years of life. Disruptions of the brain involving neurons, axons, dendrites, synapses, neurotransmitters or brain infrastructure produce profound changes in development and functions of the one organ that makes us unique. To understand the functions and development of the brain is difficult enough, but to reverse the consequences of trauma and repair the damage is even more challenging. To meet this challenge and increase understanding, a host of disciplines workin...
Understanding Traumatic Brain Injury
Progress in research on traumatic brain injury is presented in this timely book encompassing translational and clinical investigations. Observational and interventional studies are discussed by leading investigators of TBI in adults and children. Contributors from various countries provide a global perspective on this worldwide health problem.
From Neuroscience to Neurology
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson's disease, and migraine, were...
Cerebral Ischemia and Resuscitation
This fascinating monograph is filled with information formerly found only in periodicals and symposia proceedings. Chapters discuss the different models of cerebral ischemia in use today, including their advantages and disadvantages. This one-of-a-kind resource also contains essential chapters on cellular mechanisms of ion and acid-base homeostases, and energy metabolism of the ischemic brain. It reviews the possible role of lipids, free fatty acids, and free radicals. Four chapters are devoted to neurotransmitters and neuroregulators in cerebral ischemia. This extraordinary work also covers aspects of protection against and resuscitation from cerebral ischemia. An extremely informative volume, this book is an absolute must for every student in the field of cerebral ischemia, as well as the clinician or scientist who is already involved with this worldwide problem.
Ischemic Stroke
'... Provides an admirable review of current knowledge regarding experimental stroke research, and outlines the problems and some solutions in the clinical application of such knowledge.'
