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A historic gold coin marches across history and the world from the time of Julius Caesar to modern America--cursed in death, war, betrayal, hate and finally embraced by love and honor.
There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approach...
This two-volume-set (LNCS 8384 and 8385) constitutes the refereed proceedings of the 10th International Conference of Parallel Processing and Applied Mathematics, PPAM 2013, held in Warsaw, Poland, in September 2013. The 143 revised full papers presented in both volumes were carefully reviewed and selected from numerous submissions. The papers cover important fields of parallel/distributed/cloud computing and applied mathematics, such as numerical algorithms and parallel scientific computing; parallel non-numerical algorithms; tools and environments for parallel/distributed/cloud computing; applications of parallel computing; applied mathematics, evolutionary computing and metaheuristics.
This textbook provides a comprehensive overview of the state of the art knowledge of breast cancer management for the modern breast surgeon. It covers all aspects of multidisciplinary care including primary breast and axillary surgery, reconstruction and oncoplastic techniques, external beam radiotherapy and newer techniques such as tomotherapy, intraoperative radiotherapy and brachytherapy. In addition, systemic therapies including chemotherapy, the latest biological targeted therapies and endocrine therapies are covered. Readers can find out about other important aspects of breast cancer such as genetics, screening, imaging and long-term health among others. Chapters take the reader throug...
The seventies were a decade of groundbreaking horror films: The Exorcist, Carrie, and Halloween were three. This detailed filmography covers these and 225 more. Section One provides an introduction and a brief history of the decade. Beginning with 1970 and proceeding chronologically by year of its release in the United States, Section Two offers an entry for each film. Each entry includes several categories of information: Critical Reception (sampling both '70s and later reviews), Cast and Credits, P.O.V., (quoting a person pertinent to that film's production), Synopsis (summarizing the film's story), Commentary (analyzing the film from Muir's perspective), Legacy (noting the rank of especially worthy '70s films in the horror pantheon of decades following). Section Three contains a conclusion and these five appendices: horror film cliches of the 1970s, frequently appearing performers, memorable movie ads, recommended films that illustrate how 1970s horror films continue to impact the industry, and the 15 best genre films of the decade as chosen by Muir.
With a career in films spanning nearly fifty years, Burt Lancaster brought his unique charisma and energy to roles in films ranging from the adventurous to the bittersweet. This comprehensive filmography of Lancaster's career is accompanied by a biography that provides the background for his immense range of work on the screen. Production information, a synopsis, and commentary is provided for each of Lancaster's 85 films, from the first--The Killers--to the last--Separate But Equal. Photographs from nearly all of Lancaster's films accompany the text, and an index and bibliography are also included.
Coating opera's roles in opulence, Maria Callas (1923-1977) is a lyrical enigma. Seductress, villainess, and victor, queen and crouching slave, she is a gallery of guises instrumentalists would kill to engineer… made by a single voice. But while her craftsmanship has stood the test of time, Callas’ image has contested defamation at the hands of saboteurs of beauty. Twelve years in the making, this voluminous labour of love explores the singer with the reverence she dealt her heroines. The Callas Imprint: A Centennial Biography reaps never-before-seen correspondence and archival documents worldwide to illustrate the complex of their multi-faceted creator - closing in on her self-contradictions, self-descriptions, attitudes and habits with empathic scrutiny. It swivels readers through the singer's on- and offstage scenes and flux of fears and dreams... the double life of all performers. In its unveiling of the everyday it rolls a vivid film reel starring friends and foes and nobodies: vignettes that make up life. It's verity. It's meritable storytelling. Not unlike the Callas art.
With humor and empathy, Dana Brantley-Sieders explores the science and realities of breast cancer for the love of your boobs and your life. Dana Brantley-Sieders spent twenty years working as a biomedical breast cancer researcher. Then, she was diagnosed with breast cancer. She thought she knew breast cancer before it whacked her upside her left boob and left her bleeding on the curb of uncertainty. Turns out, she had a lot to learn. This book shares Brantley-Sieders’ personal journey with breast cancer, from the laboratory bench to her own bedside, and provides accessible information about breast cancer biology for non-scientists. Talking to My Tatas: All You Need to Know from a Breast Ca...