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Epigenetic and Metabolic Regulators of Breast Carcinogenesis
Breast cancer is the most common tumor in females worldwide. Cancer epigenetics and metabolic reprogramming are known cancer hallmarks. Recent advances in the field of epigenetics include histone modification, DNA methylation, and non-coding RNAs. In contrast to genetic modifications, epigenetics refers to a set of dynamic alterations. By controlling the on and off states of oncogenes and tumor suppressor genes, as well as re-engineering the tumor microenvironment, epigenetics plays a crucial role in the initiation and progression of carcinogenesis. Additionally, the complex process of metabolic reprogramming is required for both malignant transformation and tumor development, including invasion and metastasis. Furthermore, reprogrammed metabolic activities have been utilized to diagnose, monitor, and treat cancer patients. In tumor tissues, metabolic heterogeneity was found to take a role in the adaptation to the microenvironment drastic changes resulting from current therapeutic modalities.
Trinacrime
TRINACRIME - Story of a Mafia Repentant, by Alessandro VizzinoThis is the story, in novel form, of one of the most relevant exponents of Catania's "Cosa Nostra" in the 1980s and 1990s. TRINACRIME - Story of a Mafia RepentantCatania, San Cristoforo neighborhood, early 1970s. Tonio is the son of a shoemaker, which is why they call him "lu Scarparu." Even as a child, he is a rebel with little interest in school and is more drawn to petty theft. His bravado and desire for freedom lead him to leave Catania to escape to Milan. There he is initiated into robbery and experiences his first prison term.Back in Catania, he acts with his gang, pulling off several hits that put him ingood standing with t...
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PET/CT in Radiotherapy Planning
This pocket book offers a succinct but comprehensive overview of the role of PET/CT in radiotherapy planning. Individual chapters are devoted to specific application of the technique to particular tumor types, including non-small cell lung, gastrointestinal, head and neck squamous cell, prostate, gynecological, and pediatric tumors. Helpful information is also presented on the practical implementation of PET/CT in routine oncological practice. Technical and logistical issues are discussed, and guidance provided on potential problems and pitfalls and available solutions. The book will be invaluable in assisting readers to exploit PET/CT’s ability to significantly improve delineation of tumor tissue through the addition of metabolic information to structural imaging data, thereby avoiding unnecessary radiation injury and associated complications while enhancing therapeutic effects and minimizing the risk of marginal recurrences. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, compiled under the auspices of the British Nuclear Medicine Society.
