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Dancing around the Hill
In the 1970s, Canada’s cities are rife with political turmoil. Journalist Tony Muldoon capitalizes on the copious scandals and underhanded election games in his column, “Dancing around the Hill,” featured in the Ottawa Tribune. His career is on the fast track, complete with a promotion and bigger paycheck, but living the high life isn’t as great as he hoped. His marriage is a façade of jealousy and anger, and soon, all the scandalous dirt he’s been digging up might bury him. It’s true: Ottawa is a place of power, but some politicians and senior bureaucrats that walk her fine streets are anything but pure of heart. These men and women are hungry for control, and they will do anyt...
Iron Physiology and Pathophysiology in Humans
Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and ot...
Victoria, Queen of the Screen
Both in life and death, Queen Victoria is among the most popular monarchs to be committed to film. Her reign was characterized by an explosion in media coverage that began to rely on images rather than words to tell her story. Even though Victoria has been labeled the "first media monarch," the sheer magnitude of her screen presence has been neither chronicled nor fully appreciated until now. This book examines the growth and evolution of Queen Victoria's on-screen image. From the satirical cartoons and silent films of the 19th century to the television shows, video games, and webcomics of the 21st, it demonstrates how the protean Victoria character has evolved, ultimately meaning many different things to many different people in many different ways. Each chapter looks at a facet of her character and includes analysis of how these media present Queen Victoria as a real person and shape her as a character acting within a narrative. The book includes a comprehensive and international filmography.
Molecular and Cellular Iron Transport
This text analyzes the molecular mechanisms, chemical behaviour and regulation of iron transport in biological systems and offers novel methods for the assessment of iron transport across biological membranes. It details the characteristics and consequences of iron deficiency and excess to prevent diseases affecting major organ structures and promote bodily iron homeostasis.
Iron Metabolism
Iron has various functions in the body, including the metabolism of oxygen in a variety of biochemical processes. Iron, as either heme or in its "nonheme" form, plays an important role in key reactions of DNA synthesis and energy production. However, low solubility of iron in body fluids and the ability to form toxic hydroxyl radicals in presence of oxygen make iron uptake, use and storage a serious challenge. The discovery of new metal transporters, receptors and peptides and as well as the discovery of new cross-interactions between known proteins are now leading to a breakthrough in the understanding of systemic iron metabolism. The objective of this book is to review and summarize recent developments in our understanding of iron transport and storage in living systems.
Clinical and Statistical Considerations in Personalized Medicine
Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subseq...
The Nobel Prizes 2019
The Nobel Prizes is the official yearbook of the Nobel Foundation. This edition provides extensive information about the 2019 laureates: their Nobel Prize lectures and their autobiographies, as well as presentation speeches and background about the Nobel festivities.Published on behalf of the Nobel Foundation.
The Importance Of Iron In Pathophysiologic Conditions
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protei...
