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This book develops a conceptual framework for the relationship between organisation and output, and applies it to the analysis of German and British export support services. These findings help to explain why one organisation may be different from another, but equally effective and efficient, and why no panacea for effective and efficient organisation has been found. They also suggest angles from which existing organisations and blueprints of ‘better’ organisations can be examined.
Planning and the Political Market argues that the enthusiasm for planning as an essential component of environmental protection is misplaced. Drawing on the experience of Britain and other Western democracies, the author uses public choice theory to explore the practical experience of land use planning as an example of government failure. The book opens by outlining the institutional focus of public choice theory, examining the central questions of market and government failure and the theoretical case for government intervention in the environment. Having explored the principal impacts of planning the book goes on to analyse the institutional structures which have produced these policy outcomes. The analysis suggests that institutional incentives within the 'political market' have frequently led to policies which favour special interest groups and public sector bureaucracy. The book concludes with an assessment of the potential for a private property rights, free market alternative to increase community involvement and access.
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Theorizes the experiences of women in wartime, and specifically of African women during Zimbabwe's anti-colonial struggle. A Zimbabwe-specific study, focusing on the lives of women in a small locale (Chiweshe) during the anti-colonial insurgency, this book is also a challenge to established and still current modes of thought and research orientationswhich over-simplify the complex realities women face in the full range of violent conflicts, both past and present. By contextualizing the voices of women of Chiweshe, not only is an important and under-developed aspect of Zimbabwean and African history revealed, but a new approach to comprehending the highly-tensioned lives of women in war is pr...
This book uniquely summarizes approaches to developing dermatological drugs in a regulated environment from the perspective of the pharmaceutical industry. It brings together the insights of skilled and experienced industry experts to reveal the complexities of dermatological drug development, covering topical, oral, and biologic drugs. This book fills an important gap, as there is currently no other textbook addressing dermatological drug development, explaining and illustrating why unique nonclinical and clinical studies are necessary and how they are typically designed and conducted. The drug development process is also an evolving strategy that is characterized by communicating, negotiating, and agreeing with regulatory agencies, such as FDA (US), EMA (EU), and PMDA (Japan).
Examining the consequences of technology-driven lifestyles for both crime commission and victimization, this comprehensive Handbook provides an overview of a broad array of techno-crimes as well as exploring critical issues concerning the criminal justice system’s response to technology-facilitated criminal activity.
Isoprenoids are important in primary and secondary metabolism. They have implications in a myriad of physiological processes notably in plants, microorganisms and parasites, and biological activities at the cellular, organism, and ecosystem levels. The importance of isoprenoids in various areas of the scientific world has spurred intense research worldwide. Also their role in "nutraceuticals" has stimulated scientific curiosity. Literature on isoprenoids is widely scattered in journals with quite differing readerships and geographic distribution. A comprehensive book on isoprenoids does not exist. Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches fills this gap by presenting the latest and the most applicable information on isoprenoids. The most recent TERPNET conference serves as the backdrop and provides much of the inspiration for the topics covered in the book. Additional topics of interest are covered as well, making Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches the most comprehensive review of isoprenoid synthesis to date.
Military Intelligence and the Arab Revolt examines the use and exploitation of intelligence in formulating Britain’s strategy for the Arab Revolt during the First World War. It also presents a radical re-examination of the achievements of T.E. Lawrence (Lawrence of Arabia) as an intelligence officer and guerrilla leader. Modern intelligence techniques such as Sigint, Imint and Humint were incorporated into strategic planning with greater expertise and consistency in Arabia than in any other theatre during the war, and their deployment as tactical support for the Arab forces was decisive. Using much previously unpublished material, this study shows conclusively how Britain’s intelligence ...
This state-of-the-art text describes the science behind the system and drug-dependent components of PBPK models, its applications in translational and regulatory science, e.g., guiding drug discovery and development, and supporting precision medicine initiatives. To incorporate state-of-the-art knowledge, each chapter is written by leaders in the field and illustrated by clear case studies. Connecting basic and applied science, this book explores the potential of PBPK modeling for improving therapeutics and is designed for a wide audience encompassing graduate students as well as biopharmaceutics scientists and clinical pharmacologists. Features: 1. Provides a basic understanding of the physiologically-based pharmacokinetic modeling and its applications 2. Assists the reader in understanding product performance to allow for rapid product development and establish bioequivalence 3. Well-constructed content and added value of real examples 4. Illustrates how using available resources via modeling and simulation leads to a reduction in the costs related to drug development, which directly affects the costs to patients
Strigolactones, Alkamides and Karrikins in Plants: Recent Updates and Future Prospects provides comprehensive knowledge on the various aspects of plant growth, physiology, and communication associated with the three potential biomolecules. Strigolactones have gained much importance in the last decade as potential plant growth regulators. Likewise, alkamides are also known for their plant growth regulatory and pharmacological properties. The evolutionary significance of karrikins as a potential signaling molecule in different plant groups has been fascinating to plant physiologists and ecologists. This book enables the reader to gain insights into the myriad role of these biomolecules in plan...