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RNA-Binding Antibiotics
The past several years have seen a fundamental change in our perception of RNA. RNA was once regarded as a passive mediator of genetic information in mRNA and tRNA or as a mere scaffold for proteins in the ribosome. But the discovery of catalytic RNA, the development of SELEX, and dramatic improvements in RNA structure analysis have rather demonstrated that RNA is a highly versatile and dynamic molecule. Our increased understanding of the important role RNA plays in most, if not all, cellular processes has lead to the awareness that RNA represents a potential and prominent target for therapeutic intervention. On one hand, nature has "invented" an innumerable amount of small compounds which b...
