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With this valuable practical guide, three members of the Harvard Stem Cell Institute have compiled and edited the definite handbook for the exciting new field of human embryonic stem cell research. The editors have gathered protocols from scientists with extensive reputation and expertise, describing and comparing currently used techniques for the culture of human stem cells and discussing the strengths and weaknesses of the different approaches. Human Embryonic Stem Cells: The Practical Handbook contains the first centralised collection of methods used in human embryonic stem cell biology. The book covers the derivation of human stem cell lines, the obtaining of cells from human stem cell b...
A landmark book by the senior science writer at Time magazine introduces us to a medical breakthrough that can save our lives. Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science that will revolutionize medicine and change the way we think about and treat disease. Alice Park takes us from stem cell's controversial beginnings to the recent electrifying promise of being able to create the versatile cells without using embryos at all. She shows us how stem cells give researchers an unprecedented ability to study disease while giving patients the promise of replacing diseased cells with healthy new ones. And she profiles the scientists and leaders-many with their own compelling stories-who have fueled the quest and will continue to shape the field in years to come.
. By sailing in the wake of their ancestors, the Hawaiians and other Polynesians who captained, navigated, and crewed Hokulea made the long journey described in Voyage of Rediscovery a truly cultural as well as scientific odyssey of exploration into their ancestral past.
In the summer of 1985, a mostly Hawaiian crew set out aboard Hokule'a, a reconstructed ancient double canoe, to demonstrate what skeptics had steadfastly denied: that their ancestors, sailing in such canoes and navigating solely by reading stars, ocean swells, and other natural signs, could intentionally have sailed across the Pacific, exploring the vast oceanic realm of Polynesia and discovering and settling all its inhabitable islands. Their round-trip odyssey from Hawai'i to Aotearoa (New Zealand), across 12,000 nautical miles, dramatically refuted all theories declaring that—because of their unseaworthy canoes and inaccurate navigational methods—the ancient Polynesians could only hav...
This abridged version of the bestselling reference Handbook of Stem Cells, Two-Volume Set attempts to incorporate all the essential subject matter of the original two-volume edition in a single volume. The material has been reworked in an accessible format suitable for students and general readers interested in following the latest advances in stem cells, including full color presentation throughout. Although some extra language and chapters have been deleted, rigorous effort has been made to retain from the original two-volume set the material pertinent to the understanding of this exciting area of biology.The organization of the book remains largely unchanged, combining the prerequisites f...
Accompanying CD-ROM (in v. 2) has image collections which can be saved in PowerPoint or HTML.
Looking back on a memorable career, Darren McCarty recounts his time as one of the most visible and beloved members of the Detroit Red Wings as well as his personal struggles with addiction, finances, and women and his daily battles to overcome them. As a member of four Red Wings' Stanley Cup&–winning teams, McCarty played the role of enforcer from 1993 to 2004 and returning again in 2008 and 2009. His “Grind Line” with teammates Kris Draper and Kirk Maltby physically overmatched some of the best offensive lines in the NHL, but he was more than just a brawler: his 127 career goals included several of the highlight variety, including an inside-out move against Philadelphia in the clinching game of the 1997 Stanley Cup Finals. As colorful a character as any NHL player, he has arms adorned with tattoos, and he was the lead singer in the hard rock band Grinder during the offseason. Yet this autobiography details what may have endeared him most to his fans: the honest, open way he has dealt with his struggles in life off the ice. Whether dealing with substance abuse, bankruptcy, divorce, or the death of his father, Darren McCarty has always seemed to persevere.
Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative r...
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