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Jacob Burki came from Rotterdam (probably originally from Switzerland) to what is now Berks County, Pennsylvania in 1733. Descendants live in many states.
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and m...
This issue of Veterinary Clinics: Small Animal Practice, guest edited by Dr. Elisa Mazzaferro, focuses on Emergency and Critical Care of Small Animals. This is one of six issues each year. Articles in this issue include, but are not limited to: Cardiopulmonary Resuscitation in Small Animals; Transfusion Medicine in Small Animals; Extracorporeal Therapies in the ER and ICU; Respiratory Emergencies; Ocular Emergencies in the Small Animal Patient; Biosecurity Measures in Small Animal Practice; Albumin Therapy in Critical Illness; Canine Parvoviral Enteritis; Therapeutic Strategies in IMHA; Use of Antithrombotics in Critical Illness; Use of Intravenous Immunoglobulin in Clinical Practice; Use of Intravenous Immunoglobulin in Clinical Practice; Resuscitative Strategies for the Small Animal Trauma Patient; Use of Thromboelastography in Clinical Practice; Nutritional Support of the Critical Patient; Update on Anticonvulsant Therapy for the Small Animal Patient; Total Intravenous Anesthesia for the Small Animal Critical Patient; and Cageside Ultrasound in the ER and ICU.
Shows parents how to use their toddler's play as an opportunity for learning.