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Animal Allergens: Common Protein Characteristics Featuring their Allergenicity
Among the many molecules present in our environment, some have the property to induce allergic sensitization and IgE-mediated reactions. The analysis of known major animal allergens has shown that most belong to single protein families: lipocalins and serum albumins for inhalant allergens, EF-hand proteins, tropomyosins and caseins for the digestive allergens. The finding that allergens are often clustered in large families may be related to the fact that common structural, biochemical or functional features contribute to their allergenicity, in addition to external adjuvant factors. Currently, there is no curative treatment for animal allergy available. In order to lower allergic reactions to respiratory allergens in daily life and to food allergens upon accidental exposure, it is important to desensitize concerned patients. Tolerance induction by allergen-specific immunotherapy is in the current focus of an ambitious research. This Research Topic aims to provide a comprehensive view of the basic and recent insights on the allergenicity of animal allergens in view of their structural and functional aspects as well as allergen-specific immunotherapy.
Encyclopedia of Food Allergy
Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to...
Molecular Allergy Diagnostics
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. Th...
Nomenclature: Avoiding Babylonian Speech Confusion in Present Day Immunology
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). A/Prof. Menno van Zelm currently serves as the chairman for the IUIS Nomenclature Committee; Prof. Pablo Engel is the chair of the IUIS CD Nomenclature Sub-Committee; Prof. Loems Ziegler-Heitbrock is the chair of the IUIS Monocytes and Dendritic Cells in Blood Sub-Committee; Asst. Prof. Sanny Chan is a member of the WHO / IUIS Allergen Nomenclature Sub-Committee and A/Prof. Andrew Collins is co-chair of the Germline Gene Database (GLDB) Working Group of the Adaptive Immune Receptor Repertoire community (AIRR-C) and chair of the Inferred Allele Review Committee (IARC).
Oncogene
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Food Allergy
Food allergy is an adverse immunological reaction to allergens present in food. Up to 4% adults and 8% children are affected by food allergy. The increase in allergic diseases to food has led to the need for better diagnostics and more effective therapeutic approaches. This book describes the molecular biology and immunology of major food allergens, from laboratory based science to clinical immunology, encompassing novel characterisation and quantification methods, the application of recombinant food allergens in molecular diagnosis and the development of novel therapeutics. This book is the ideal reference tool for researchers, students and allergy clinicians to accurately diagnose and manage food allergies.
Allergens and Allergen Immunotherapy
The sixth edition of Lockey and Ledford's Allergens and Allergen Immunotherapy continues to provide comprehensive coverage of all types of allergens and allergen vaccines, providing clinicians the essential information they need to accurately diagnose and manage all allergic conditions. With new and updated chapters, the sixth edition is the most up-to-date, single resource on allergy and immunotherapy. Key Features Completely revised and updated Detailed single source reference on allergy and immunotherapy Reorganized to provide clinicians with essential information to make diagnoses and offer the best treatments
Molekulare Allergiediagnostik
Das Buch bündelt aktuelle Fakten zur molekularen Allergologie und zeigt ihre Vorteile für die moderne Allergiediagnostik. Zunächst werden die wichtigsten Proteinfamilien mit Allergenen ähnlicher Struktur vorgestellt. Einzelallergene verbessern vor allem die Treffsicherheit von IgE-Bestimmungen, deren Testvarianten ausführlich erläutert werden. Anhand häufiger Allergenquellen — Inhalations-, Nahrungsmittel- und Insektengiftallergene — werden dann Nutzen und Grenzen einer molekularen Allergiediagnostik im klinischen Alltag aufgezeigt. Der letzte Abschnitt stellt potenzielle Anwendungen der molekularen Allergologie vor, z. B. die Entwicklung rekombinanter Allergenvakzine oder hypoallergener Nahrungsmittel. Das Buch erweitert die erfolgreiche Beitragsserie „Im Fokus: Molekulare Allergologie“ aus dem Allergo Journal von Springer Medizin und beschreibt die junge Disziplin der molekularen Allergologie als ein sich rasch entwickelndes Fachgebiet. Dabei liefert es wertvolle Hinweise für dieUmsetzung im klinischen Alltag und hilft, die Diagnostik, Beratung und Versorgung allergischer Patienten zu verbessern.
Leviathans
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