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According to the most updated epidemiological studies, cardiovascular disease remains a leading cause of death; in fact, despite substantial advances in the care of patients, the incidence of cardiovascular disorders continues to increase. Therefore, the search for novel mechanisms and therapeutics is desperately needed, and translational studies represent the best strategy to uncover novel therapeutic targets, reduce mortality, and improve the quality of life. This book gathers original articles and systematic reviews that have both a strong basic research background and clear translational potential. All the studies have been peer reviewed by at least two experts in the field. These contributions provide an updated systematic overview that examines, in detail, the mechanisms of the main cardiovascular and metabolic disorders, including ischemic and non-ischemic heart failure, hypertension, thromboembolism, atherosclerosis, stroke, diabetes mellitus, dyslipidemia, metabolic syndrome, valvulopathies, peripheral artery disease. In the final chapter, the functional role of the endothelium in the systemic manifestations of COVID-19 is described.
Explore all five senses and learn how all of these senses work together to help humans perceive their environment. Detailed diagrams and photos taken with a magnifying camera show how the body works to help students see, smell, touch, taste and hear! Readers will make science and language arts connections with vocabulary related to the function of the five senses.
This book provides a comprehensive analysis of the rules governing the taxation of permanent establishments as implemented in the OECD Model Tax Convention and German national tax law. Deviations between the OECD approach and the German approach are identified and modifications to the rules as a result of the Base Erosion and Profit Shifting (BEPS) project are examined. Moreover, challenges imposed to the PE concept as a result of the digitalisation of the economy are identified and discussed. Against this background, the Pillar One Blueprint proposing a long-term solution to overcome the tax challenges arising from the digitalisation of the economy is presented and assessed against widely accepted overarching principles of tax policy.
Zusammenstellung der Nachfahren von Hans Hildebrand Ziegenfuß, der um 1650 im Eichsfeld in Thüringen lebte. Die 3. Auflage enthält die Daten von mehr als 22.000 bekannten Nachkommen (Stand Dezember 2021). Die aktuellen Daten finden sich auf der Homepage unter https://www.ziegenfuss-genealogy.de Schlagworte: Ahnenforschung, Stammbaum, Ziegenfuß, Ziegenfuss, Eichsfeld, Genealogie, Genealogy, Marco Born
Joan-Pau Rubiés brings together here eleven studies published between 1991 and 2005 that illuminate the impact of travel writing on the transformation of early modern European culture. The new worlds that European navigation opened up at the turn of the 16th century elicited a great deal of curiosity and were the subject of a vast range of writings, much of them with an empirical basis, albeit often subtly fictionalized. In the context of intense literary and intellectual activity that characterized the Renaissance, the encounters generated by European colonial activities in fact produced a remarkable variety of images of human diversity. Some of these images were conditioned by the actual ...
Located at the confluence of the north and west branches of the Susquehanna River, Shamokin was a significant historical settlement in the region that became Pennsylvania. By the time the Moravians arrived to set up a mission in the 1740s, Shamokin had been a site of intertribal commerce and refuge for the Native peoples of Pennsylvania for several centuries. It served first as a Susquehannock, then a Shawnee, and then a primarily Lenape settlement and trading post, overseen by the Oneida leader and diplomat Shikellamy. Cultures at the Susquehanna Confluence is an annotated translation of the diaries documenting the Moravian mission to the area. Unlike other missions of the time, the Moravia...
A consolidation of the many articles regarding ship passenger lists previously published.