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Specialized Metabolites from Medicinal Plants: the Structural Identification, Biological Activity and Biosynthesis Pathways
Morphine, extracted/isolated from the opium poppy, was the first plant-derived natural product, which was first reported in 1806 and marked as the beginning of plant metabolites research. In the following 200 years, many specific metabolites with significant bio-activity, such as quinine, artemisinin, and paclitaxel, were discovered in plant-derived medicines and have been used for treating human diseases. The extracts of plants or their metabolites have contributed significantly to human health, particularly in the treatment of chronic diseases such as diabetes, hypertension, and obesity. Nowadays, medicinal plants and their metabolites are increasingly favored by researchers and pharmaceutical companies to be developed as new dietary supplements and pharmaceuticals. Therefore, screening and identification of novel active metabolites or lead compounds from plant-derived medicines for human disease treatment have become a popular research area.
Natural Products
Phytonutrients - The natural drugs of the future -- Research on the supercritical CO, extraction of Xinyang MaoJian tea -- Applications of RNAi technology -- Enhancing bioactive molecules in medicinal plants -- Biotransformation of taxanes from cell cultures of Taxus sp -- Biotransformation of terpenes and steroids by fungi -- Rapid analysis of triterpenoid saponins in plant extract Using ESI-MSn and LC-MSn -- HPLC-MS Analysis of phenolic constituents of PhyZZanthus Amarus -- Structure elucidation of norditerpene alkaloids from Ranunculaceae species -- Quantitative detection of isoflavones in the extract of Red Clover by HPLC/ESI-MS -- Measurement of bioactive constituents in traditional chi...
Research Grants
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Shengmai San
Traditional Chinese medicine commonly prescribes herbal formulas for the prevention and treatment of diseases. Shengmai San, a famous Chinese medicinal formula that has been used for more than eight hundred years in China, is comprised of Radix Ginseng, Fructus Schisandre and Radix Ophiopogonis. Traditionally, Shengmai San is used for the treatment
Plant Natural Products for Human Health
Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resu...
