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Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies
Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) an...
Potassium Channels
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Rook's Textbook of Dermatology
The latest edition of the world’s leading dermatology textbook Rook’s Textbook of Dermatology, 10th Edition is the most definitive, comprehensive and illustrated reference work in dermatology worldwide. Fully updated by experts from around the world, the book highlights the latest key evidence-based developments in pathogenesis, diagnosis and treatment of skin disorders. A highly intuitive resource and invaluable clinical companion for both those training and those fully qualified in dermatology, other highlights of Rook’s Textbook of Dermatology, 10th Edition include: 1. Comprehensive review of essential basic science, skin biology and pharmacology 2. More than 3000 clinical illustrat...
Pediatric Dermatopathology
This book provides practicing pathologists, dermatologists, cutaneous oncologists and dermatopathologists with a reference textbook that reviews the clinical and histopathologic features of skin disorders that affect children, along with a discussion of the molecular pathogenesis for each disease as it is currently known. The book includes a concise discussion of the clinical presentation, as well as the histologic and, when appropriate, immunohistochemical features of each disease. The book is divided into two main sections, non-neoplastic and neoplastic skin diseases. Each section is comprised of a series of chapters organized according to histologic findings rather than by clinical classi...
Gaceta Oficial
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Land Allocation for Biomass Crops
This edited volume establishes a forum for international experts to explore cutting-edge questions associated with the land use and biomass production. Topics include ‘do we have enough land, either primary or marginal, to accommodate future production of biomass?’, ‘how are farming decisions made in response to biomass incentives?’, ‘is the current bio-mass production socially, economically and environmentally sustainable?’, and ‘what are the main constraints currently limiting biofuel deployment?’ The expansion of biomass production is often at the cost of reduced land availability for food production and losses of areas with ecological functions such as forests and wetlands. This process often involves complex interplay of physical dynamics and human systems that are driven by numerous geographic and socio-economic factors at different scales. Thus, the state-of-the-art research on the land use issues surrounding the biomass production and its environmental impacts is important for informed land management decision making. This book will be of great use to researchers in land use management and biomass-based renewable energy, as well as practitioners.
