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Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics
  • Language: en
  • Pages: 260

Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics

This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bone; cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.

Insulin-like Growth Factor Receptor Signalling
  • Language: en
  • Pages: 524

Insulin-like Growth Factor Receptor Signalling

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Hormones and Cancer: Breast and Prostate, An Issue of Endocrinology and Metabolism Clinics of North America
  • Language: en
  • Pages: 265

Hormones and Cancer: Breast and Prostate, An Issue of Endocrinology and Metabolism Clinics of North America

This issue of Endocrinology Clinics brings the reader up to date on the latest information about hormones and cancer of the breast and prostate. The first section focuses on the breast, and topics covered include the following. The role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; hormonal mechanisms underlying the relationship between obesity and breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; aromatase inhibitors, anti-estrogen and SERMS in the treatment of breast cancer; and androgens in breast cancer in men and women. The second section is devoted to the prostate, and topics covered in...

Endocrine Disorders During Pregnancy, An Issue of Endocrinology and Metabolism Clinics of North America
  • Language: en
  • Pages: 239

Endocrine Disorders During Pregnancy, An Issue of Endocrinology and Metabolism Clinics of North America

This issue of Endocrinology Clinics covers essential updates in a range of common endocrine disorders that are of special concern during pregnancy, as well as endocrine problems that can arise due to pregnancy. A variety of thyroid, pituitary, adrenal, and hypertensive disorders are covered, as well as calcium and bone metabolism disorders during pregnancy and lactation. Diagnosis and treatment of gestational diabetes, and pregestational diabetes are addressed. Iodine disorders in pregnancy and lactation are covered. Hyperprolactinemia and infertility are also addressed. Special concerns of obesity in women with reproductive dysfunction are considered. An in-depth guide to achieving a successful pregnancy with PCOS is provided

Neuroendocrine Control of Metabolism, An Issue of Endocrinology and Metabolism Clinics
  • Language: en
  • Pages: 344

Neuroendocrine Control of Metabolism, An Issue of Endocrinology and Metabolism Clinics

This issue of Endocrinology Clinics brings the reader up to date on the important advances in research surrounding the neuroendocrine control of metabolism. Guest edited by Christoph Buettner, the topics covered include leptin signaling, hypothalamic inflammation, hypoglycemia awareness, perinatal programming of metabolic disease, substrates, and more.

Insulin-Like Growth Factors
  • Language: en
  • Pages: 134

Insulin-Like Growth Factors

  • Type: Book
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  • Published: 2004
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  • Publisher: IOS Press

Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This pu...

Current Perspectives on Insulin-like Growth Factor Binding Protein (IGFBP) Research
  • Language: en
  • Pages: 148

Current Perspectives on Insulin-like Growth Factor Binding Protein (IGFBP) Research

The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are lo...

Journal of Cell Science
  • Language: en
  • Pages: 440

Journal of Cell Science

  • Type: Book
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  • Published: 2002
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  • Publisher: Unknown

None

Insights in Cancer Endocrinology: 2021
  • Language: en
  • Pages: 135

Insights in Cancer Endocrinology: 2021

None

Inflammation, Oxidative Stress, and Cancer
  • Language: en
  • Pages: 631

Inflammation, Oxidative Stress, and Cancer

  • Type: Book
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  • Published: 2016-04-19
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  • Publisher: CRC Press

Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and