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The Individual Microbe: Single-Cell Analysis and Agent-Based Modelling
Recent technological advances in single-cell microbiology, using flow cytometry, microfluidics, x-ray fluorescence microprobes, and single-cell -omics, allow for the observation of individuals within populations. Simultaneously, individual-based models (or more generally agent-based models) allow for individual microbes to be simulated. Bridging these techniques forms the foundation of individual-based ecology of microbes (µIBE). µIBE has elucidated genetic and phenotypic heterogeneity that has important consequences for a number of human interests, including antibiotic or biocide resistance, the productivity and stability of industrial fermentations, the efficacy of food preservatives, an...
Development of a Simulator to Evaluate Public Health Control Strategies of Tuberculosis in Big Cities
Tuberculosis is still one of the most important infectious diseases worldwide, killing over 1.5 million people each year. It is estimated that one third of world population has already been infected by Mycobacterium tuberculosis. In particular, the Ciutat Vella neighbourhood in Barcelona has a tuberculosis incidence which is comparable with the incidence in countries like Sudan. In this work we have improved a previous agent-based model, and we used it to develop a simulator of the tuberculosis dynamics in Ciutat Vella, as a first step towards the simulation of tuberculosis dynamics in big cities. The model was implemented in NetLogo, a free and open-source agent-based simulation tool that i...
Development and Analysis of Mathematical Methods to Evaluate the Effects of High Hydrostatic Pressure Sublethal Treatment in Listeria Monocytogenes Cultures
Every year there are millions of cases of diseases caused by food pathogens. Therefore, food safety is one of the most important challenges in the food industry. One of the most important pathogens is Listeria monocytogenes, due to the high mortality and its high resistance against conventional methods of conservation. High hydrostatic pressure (HHP) treatment is an efficient method with good prospects of implementation in the food industry. In this project, the effects of HHP sublethal treatment on cultures of different strains of Listeria monocytogenes were analysed through mathematical methods. The experimental data used in this project were obtained mainly by Bioscreen. The experimental ...
Galicia No Tempo
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Crònica lingüística d'una pandèmia anunciada
Aquesta és una «crònica lingüística i discursiva» de com es va conceptualitzar i presentar la pandèmia de la COVID-19 en el període que va des dels inicis, al febrer de 2020, fins al juny de 2021. Basant-se en conceptes de la retòrica i l’anàlisi del discurs –com la metàfora, el símil o la multimodalitat–, i de la terminologia –com els neologismes o la creativitat lèxica– reflexiona, en un to divulgatiu però rigorós des d’un punt de vista teòric, sobre la relació entre llenguatge i pandèmia. L’obra desgrana els episodis més destacats d’aquell període explicats gairebé en directe a partir de notícies i altres testimonis procedents dels mitjans de comunicació.
Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response, Volume II (volume I.B)
Almost nine months since the first recorded case, the novel betacoronovirus; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now passed 18 million confirmed cases. The multi-disciplinary work of researchers worldwide has provided a far deeper understanding of COVID-19 pathogenesis, clinical treatment and outcomes, lethality, disease-spread dynamics, period of infectivity, containment interventions, as well as providing a wealth of relevant epidemiological data. With 27 vaccines currently undergoing human trials, and countries worldwide continuing to battle case numbers, or prepare for resurgences, the need for efficient, high-quality pipelines for peer-reviewed research remains as crucial as ever.
Modelling and Simulation of Tuberculosis Lesions Dynamics in a Minipig Bronchial Tree
Tuberculosis is a contagious disease that on 2013 killed nearly 1.5 million people. According to the Dynamic Hypothesis, once the initial lesion has been formed bronchial dissemination generates new secondary granulomas. The subsequent dynamics of growth and proliferation of lesions may lead to an active disease or remain controlled as a latent infection. The purpose of this research is to progress in the understanding of the latent tuberculosis infection in an animal model by means of analysing experimental data from infected minipigs and simulating the corresponding dynamics of lesions in a computational bronchial tree. 24 minipigs were infected with Mycobacterium tuberculosis, and after 1...
Serem Atlàntida
De l'autor de Gegants de gel, premi Llibreter 2015 i premi Crexells 2016 Som simples observadors d'un simulacre creat per guiar-nos durant la nostra existència? Aquesta és la pregunta que es planteja el nostre narrador quan coneix Mirko Bevilacqua, un home extravagant i procliu a trobar-se de manera intermitent i clandestina amb Clara, una jove que té cura d'una vella i elegant dama croata. La coneixença d'aquesta enigmàtica tríada submergeix el lector en una recerca atzarosa sobre l'autenticitat que el portarà a trepitjar els territoris de l'antiga Europa, on els espais de memòria resisteixen per no convertir-se en escenaris de la societat de l'espectacle. Utilitzant tots els recursos que li permet la narrativa, Joan Benesiu dibuixa la relació entre identitat i territori, posant el focus en el concepte de desarrelament històric i moral. Amb la nostàlgia com a aliada revisita la idea de frontera per demostrar els perills de transformar-nos en testimonis externs de la història.
