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Cancer Drug Resistance
This volume discusses the latest techniques used to identify cancer drug resistance determinants at the molecular, cellular, and functional levels. Chapters in this book cover up-to-date topics including tumor-microenvironment cell co-culture methods and microfluidics systems; workflows for functional assessment of drug resistance in vitro and in vivo; quantitative techniques for identifying quiescent blood-flow circulating cells; and single-cell characterization methods, such as mass cytometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Cancer Drug Resistance: Methods and Protocols is a valuable resource for all scientists and researchers who are looking to learn more about the latest developments in understanding and overcoming anticancer drug resistance.
Whitehead's Categoreal Scheme and Other Papers
The philosophical papers comprising this volume range from process metaphysics and theology, through the phenomenological study of intentionality, to the foundations of geometry and of the system of real numbers. New light, it is thought, is shed on all these topics, some of them being of the highest interest and under intensive investigation in contemporary philosophical discussion. Metaphysi cians, process theologians, semanticists, theorists of knowledge, phenomenologists, and philosophers of mathematics will thus find in this book, it is hoped, helpful materials and methods. The categoreal scheme of Whitehead's Process and Reality is discussed rather fully from a logical point of view in...
Ball Milling Towards Green Synthesis
Ball milling has emerged as a powerful tool over the past few years for effecting chemical reactions by mechanical energy. Allowing a variety of reactions to occur at ambient temperatures and in solvent-free conditions, ball milling presents a greener route for many chemical processes. Compared to the use of microwave and ultrasound as energy sources for chemical reactions, ball milling is not as familiar to chemists and yet it holds great potential. This book will introduce practicing chemists to the technique and will highlight its importance for green transformations. Current applications of ball milling will be covered in detail as well as its origin, recent developments and future scope, challenges and prospects. Chemical transformations covered include carbon-carbon and carbon-heteroatom bond formation, oxidation by solid oxidants, asymmetric organo-catalytic reactions, dehydrogenative coupling, peptide syntheses and polymeric material syntheses. The book will provide a valuable guide for organic, inorganic and organometallic chemists, material scientists, polymer scientists, reaction engineers and postgraduate students in chemistry.
Médecine générale pour le praticien
Premier ouvrage en langue française référent en médecine générale, ce nouveau volume de la collection «Pour le praticien» est publié sous l'égide du Collège national des généralistes enseignants. La médecine générale enfin rédigée par des généralistes ! Composé de quatre grandes parties, cet ouvrage couvre, dans une orientation Evidence Based Medicine, les domaines suivants : • la médecine générale et sa place dans le système de santé (prévention, écologie des soins de santé ...), • la communication (l'approche centrée patient, psychothérapie, questions éthiques ...), • les familles de situations de soins (patients souffrant de pathologies chroniques ou ...
Thérapeutique en Médecine Générale
Nouvelle édition entièrement actualisée, après le succès de la première Cet ouvrage est le résultat d’une collaboration originale entre l’APNET et le CNGE. Elle a permis d’associer les compétences des enseignants de Thérapeutique et des enseignants de Médecine Générale. Le contenu de chaque chapitre comprend : - un rappel clinique, - les ressources thérapeutiques disponibles, - les stratégies recommandées - et des illustrations pratiques sous forme d’ordonnances dans des situations cliniques concrètes. En plus : Les traitements validés par les données actuelles de la science sont recensés et détaillés. Le grade des recommandations est mentionné, lorsqu’il est ...
Synthesis of Metal-Organic Frameworks via Water-Based Routes
Synthesis of Metal-Organic Frameworks via Water-Based Routes: A Green and Sustainable Approach describes a sustainable approach for the synthesis of metal-organic frameworks. Bringing together chapters on the aqueous synthesis and stability of metal-organic frameworks, as well as the applications of water stable metal-organic frameworks, this timely book shows how green processing technology utilizing water as a main solvent for the synthesis of metal-organic frameworks can eliminate solvent consumption, lower investment costs and reduce energy requirements. Providing quantitative descriptions and reliable guidelines, the book summarizes the fundamental approaches and principles to prepare metal-organic frame works, highlighting the most exciting preparations and applications. - Includes the role of water in metal organic synthesis - Describes various methods of metal-organic framework preparation - Covers the industrial aspects of water-based metal-organic frameworks and potential applications
Metal-Organic Framework Materials
Metal-Organic Frameworks (MOFs) are crystalline compounds consisting of rigid organic molecules held together and organized by metal ions or clusters. Special interests in these materials arise from the fact that many are highly porous and can be used for storage of small molecules, for example H2 or CO2. Consequently, the materials are ideal candidates for a wide range of applications including gas storage, separation technologies and catalysis. Potential applications include the storage of hydrogen for fuel-cell cars, and the removal and storage of carbon dioxide in sustainable technical processes. MOFs offer the inorganic chemist and materials scientist a wide range of new synthetic possi...
