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Anti-Idiotypes, Receptors, and Molecular Mimicry
Here is an up-to-date review of important new methods and results in anti-idiotypes, receptors, and molecular mimicry. It begins with a discussion of the theoretical background of the anti-idiotypic network, it's role in the regulation of immune response, and the physical characteristics of anti-idiotypic antibodies. It then goes on to explore many exciting applications in such areas as insulin action, thyroid cell function, the neurosciences, cardiology, virology, pharmacology, and reproduction.
Immunologic Phylogeny
There are two now classic reasons for the widespread and con tinuing interest in the phylogeny of immune reactivities and structure. First is the fundamental concern of biologists with the evolution of defense mechanisms. We are eager to discover origins, mechanisms, and adaptive specializations of immunocompetence because the very existence of individuals and entire species is involved in a most essential way. Second is the strong biomedical interest in adaptive immune mechanisms to increase understanding of health and disease in man. If man and placental mammals represent the quin tessence of immunoresponsiveness with complex interdependent path ways, the less elaborate but fully functiona...
Parallel Computing: Fundamentals, Applications and New Directions
This volume gives an overview of the state-of-the-art with respect to the development of all types of parallel computers and their application to a wide range of problem areas. The international conference on parallel computing ParCo97 (Parallel Computing 97) was held in Bonn, Germany from 19 to 22 September 1997. The first conference in this biannual series was held in 1983 in Berlin. Further conferences were held in Leiden (The Netherlands), London (UK), Grenoble (France) and Gent (Belgium). From the outset the aim with the ParCo (Parallel Computing) conferences was to promote the application of parallel computers to solve real life problems. In the case of ParCo97 a new milestone was reac...
Drowning by Accident
Drowning By Accident explains why it is so easy to drown, where accidents happen, and how to save lives by early rescue and resuscitation. More than 600 people die by drowning in Britain every year. Swimming is promoted as a particularly safe form of exercise, so that swimmers forget or ignore the dangers of frigid lakes, swollen rivers, incoming tides or outgoing rip currents. Drowning accidents take place because we don't recognise water as a hostile environment. We overestimate the strength and endurance of our bodies and underestimate the power and deceptiveness of water. Year after year, victims lose their lives in typical drowning accidents, often sinking so quickly and silently that n...
Combinatorial Peptide and Nonpeptide Libraries
With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.
An Assessment and Annotated Bibliography of Marine Bioluminescence Research: 1979-1987
Publications relevant to marine bioluminescence from 1979 through 1987 are annotated and cross-indexed by author, organism studied, geographic location, and key words. Sources of research funding are discussed, and the most prolific institutions and most popular sources for publication are identified. Six areas of particular interest--namely flash characteristics, stimulation techniques, geographic and temporal distribution and occurrence and correlation with environmental parameters, the luminous organism themselves, symbiosis, and circadian rhythms are identified and analyzed for significant progress, important research omissions, and trends. No significant trends are identified, although the suggestion of the possibility of a decrease in research effort in these areas over the decade is noted. The international nature of the research is considered ... Bioluminescence, Marine biology, Optical properties.
