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How Tobacco Smoke Causes Disease
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
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Ordering Customs
Ordering Customs explores how Renaissance Venetians sought to make sense of human difference in a period characterized by increasing global contact and a rapid acceleration of the circulation of information. Venice was at the center of both these developments. The book traces the emergence of a distinctive tradition of ethnographic writing that served as the basis for defining religious and cultural difference in new ways. Taylor draws on a trove of unpublished sources—diplomatic correspondence, court records, diaries, and inventories—to show that the study of customs, rituals, and ways of life not only became central in how Venetians sought to apprehend other peoples, but also had a very real impact at the level of policy, shaping how the Venetian state governed minority populations in the city and its empire. In contrast with the familiar image of ethnography as the product of overseas imperial and missionary encounters, the book points to a more complicated set of origins.
Morphogenesis and Pathogenicity in Fungi
Infectious fungal diseases continue to take their toll in terms of human suffering and enormous economic losses. Invasive infections by opportunistic fungal pathogens are a major cause of morbidity and mortality in immuno-compromised individuals. At the same time, plant pathogenic fungi have devastating effects on crop production and human health. New strategies for antifungal control are required to meet the challenges posed by these agents, and such approaches can only be developed through the identification of novel biochemical and molecular targets. However, in contrast to bacterial pathogens, fungi display a wealth of “lifestyles” and modes of infection. This diversity makes it extr...
