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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
This book provides a detailed survey of the emotional, behavioural and cognitive disorders prevalent among patients with Multiple Sclerosis (MS), including depression, mania, psychosis, pathological laughing and crying, and cognitive dysfunction. Attention has tended to focus on the physical aspects of MS, the commonest source of neurological disability in young and middle-aged adults, but recognition and treatment of the behavioural changes associated with the disease can be equally important in improving quality of life for the patient. For each of the neuropsychiatric disorders associated with MS, clear clinical guidelines are given for diagnosis and treatment, there is a detailed review of the literature, and case vignettes are incorporated. There are chapters on screening and neuroimaging and a final chapter examines the broader concept of subcortical white matter dementia. This book will be of interest to psychiatrists, neurologists, psychologists, nurses and other professionals involved in the management of patients with MS.
Patient reported outcome measures are central to the evaluation of medical care and treatment regimes. Such measures depart from traditional clinical assessments as they are based on issues known to be of importance to patients. This book outlines the development and application of a variety of such measures in a wide range of neurological conditions. Introductory chapters outline issues in the application and validation of quality-of-life measures in neurology. Subsequent chapters survey the most widely used quality-of-life instruments in Parkinson's disease, motor neurone disease, multiple sclerosis, multiple system atrophy, progressive supranuclear palsy, and Alzheimer's/dementia. A chapter on cerebral palsy deals with the particular challenges to developing outcome measures for children. The book also addresses issues relating to the translation of measures for use in cross-cultural studies, handling missing data, carer experiences of long-term conditions, and methodological challenges. Essential reading for clinicians and researchers working in the field of neurology.
Presents a practical and accessible approach to the diagnosis and management of multiple sclerosis in hospital and outpatient settings.
Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book. - Summarizes our current understanding of Multiple Sclerosis - Discusses clinical features and available biomarker monitoring - Focuses on mechanisms that drive disease pathogenesis
This revised edition examines various aspects of the disease multiple sclerosis. It examines the advances in means of investigation, the increasing sophistication in the collection of epidemiological data and in the organization and assessment of therapeutic trials.