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Clinical MR Neuroimaging
Clinical MR Neuroimaging, second edition, provides radiologists, neuroscientists and researchers with a clear understanding of each physiological MR methodology and their applications to the major neurological diseases. Section 1 describes the physical principles underlying each technique and their associated artefacts and pitfalls. Subsequent sections review the application of MRI in a range of clinical disorders: cerebrovascular disease, neoplasia, infection/inflammation/demyelination disorders, seizures, psychiatric/neurodegenerative conditions, and trauma. This new edition includes all recent advances and applications, with greatly increased coverage of permeability imaging, susceptibility imaging, iron imaging, MR spectroscopy and fMRI. All illustrations are completely new, taking advantage of the latest scan capabilities to give images of the highest possible quality. In addition, over 35 new case studies have been included. Editors and contributors are the leading neuroimaging experts worldwide; their unique combination of technical knowledge and clinical expertise makes Clinical MR Neuroimaging the leading text on the subject.
European Handbook of Neurological Management
Evidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with ‘Recommendations’ based on strong evidence and ‘Good Practice Points’ where only weaker evidence is available. The Guidelines in this volume cover: Investigation Major neurological diseases Neuromuscular diseases Infections Neurological problems Sleep disorders Rehabilitation The European Handbook of Neurological Management provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles.
Handbook of Multiple Sclerosis
Filled with an abundance of reader-friendly and quick-reference tables and figures, this Fourth Edition spans the etiology, epidemiology, clinical features, diagnosis, pathology, and treatment of multiple sclerosis (MS). Surpassing other texts on the topic, this reference provides recommendations and research updates from renowned authorities in th
Multiple Sclerosis
A synthesis of current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of MRI, magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research and its applications to specific immunotherapies, and the use of immune markers for tracking the disease.
The Neurobiology of Multiple Sclerosis
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the "cause and the "cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
Multiple Sclerosis Immunology
The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the “new” MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and—even more—the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that “translation” is real and not just virtual.
New Frontiers of MR-based Techniques in Multiple Sclerosis
In the past few years there have been impressive advances in the implementation of modern MRI techniques for the assessment of MS patients with the ultimate goal to define MRI markers of MS evolution. The authors of this volume not only review these new techniques, such as magnetization transfer (MT) MRI, diffusion-weighted (DW) MRI and proton MR spectroscopy (MRS), that are increasingly being used to monitor MS evolution, but also those, such as functional MRI (fMRI), cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, that are emerging as additional promising tools for improving our understanding of MS pathophysiology. Strengths and weaknesses of all these modern quantitative MRI techniques for the study of MS are extensively covered in this book. The book also provides a valuable summary of the state of the art.
Multiple Sclerosis
Recent developments in basic and applied science have led to better understanding of disease mechanisms and more efficient therapies for multiple sclerosis. The most effective way of managing these patients is through a carefully planned neurorehabilitation programme. The main aims are to reduce disability and handicap and improve functions through effective training, stimulating activity and social participation. As the first text on recovery of function and neurorehabilitation in MS, this book focuses on mechanisms of recovery, application of neuroplasticity to therapeutic interventions, and determination of the efficiency of these interventions. Basic principles of neurorehabilitation in MS are described, as well as techniques for treating specific syndromes which may occur in MS. Written and edited by leading clinicians and researchers, the book achieves an excellent balance between basic science, pathophysiology, and clinical rehabilitation. An essential resource for clinicians and therapists treating patients with multiple sclerosis, neurophysiologists, and health care advisors.
Neuroscience for Neurologists
Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area.
