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Emerging Bioinformatic Tools in Toxicogenomics
Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches represents the major source of inter-study variation. This led to early attempts towards harmonizing...
Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences
Toxicogenomics combines the use of toxicology and genomic sciences to elucidate chemical, toxic and environmental stressor effects on biological systems. Integrative toxicogenomics requires innovation in bioinformatics, statistics and systems toxicology and typically a combination of the utility of two of more of these disciplines to better understand molecular mechanisms involved in toxic responses. This Frontiers in Toxicogenomics Research Topic eBook focuses on integrative toxicogenomics more so at the late stage (analyzing each data set separately and then merging the results ) and brings together analyses that combine gene expression (microarray, TempO-Seq or RNA-Seq) with other data (b...
Deep Learning for Biomedical Data Analysis
This book is the first overview on Deep Learning (DL) for biomedical data analysis. It surveys the most recent techniques and approaches in this field, with both a broad coverage and enough depth to be of practical use to working professionals. This book offers enough fundamental and technical information on these techniques, approaches and the related problems without overcrowding the reader's head. It presents the results of the latest investigations in the field of DL for biomedical data analysis. The techniques and approaches presented in this book deal with the most important and/or the newest topics encountered in this field. They combine fundamental theory of Artificial Intelligence (...
Farmageddon
The quiet revolution of mega-farming that is threatening our countryside, farms and food. 'This eye-opening book . . . deserves global recognition' Hugh Fearnley-Whittingstall 'Devastating . . . demands reading and deserves the widest possible audience' Joanna Lumley 'He is informed enough to be appalled, and moderate enough to persuade us to take responsibility for the system that feeds us' Guardian: Book of the Week Farm animals have been disappearing from our fields as the production of food has become a global industry. We no longer know for certain what is entering the food chain and what we are eating. We are reaching a tipping point as the farming revolution threatens our countryside,...
Farmagedon
Za wszystkim, co jemy, kryje się jakaś historia. Właśnie teraz gdzieś na świecie zabitych zostaje 4 tysiące zwierząt. W ciągu ostatnich dziesięcioleci zwierzęta hodowlane znikały z naszych łąk i pastwisk, bo rozrastający się przemysł hodowlany zamknął je w klatkach i boksach. Rocznie pochłania on dziesiątki miliardów niewinnych istot hodowanych na mięso, mleko i jaja, które codziennie zjadamy. Przez 3 lata Philip Lymbery podróżował po świecie i przyglądał się temu, jak wygląda „od kuchni” przemysłowa hodowla zwierząt i jak wpływa ona na ludzi, zwierzęta i planetę. Lymbery odwiedza m.in. fabryki w USA, Peru, Chinach i Meksyku. Pokazuje, jak umyślnie p...
European Access
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Handbook of Biomarkers and Precision Medicine
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, t...
