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Tumor Microenvironment
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The rea...
Searching for Life Across Space and Time
The search for life is one of the most active fields in space science and involves a wide variety of scientific disciplines, including planetary science, astronomy and astrophysics, chemistry, biology, chemistry, and geoscience. In December 2016, the Space Studies Board hosted a workshop to explore the possibility of habitable environments in the solar system and in exoplanets, techniques for detecting life, and the instrumentation used. This publication summarizes the presentations and discussions from the workshop.
Bluebird, Bluebird
A "heartbreakingly resonant" thriller about the explosive intersection of love, race, and justice from a writer and producer of the Emmy-winning Fox TV show Empire (USA Today). "In Bluebird, Bluebird Attica Locke had both mastered the thriller and exceeded it."-Ann Patchett When it comes to law and order, East Texas plays by its own rules -- a fact that Darren Mathews, a black Texas Ranger, knows all too well. Deeply ambivalent about growing up black in the lone star state, he was the first in his family to get as far away from Texas as he could. Until duty called him home. When his allegiance to his roots puts his job in jeopardy, he travels up Highway 59 to the small town of Lark, where two murders -- a black lawyer from Chicago and a local white woman -- have stirred up a hornet's nest of resentment. Darren must solve the crimes -- and save himself in the process -- before Lark's long-simmering racial fault lines erupt. From a writer and producer of the Emmy winning Fox TV show Empire, Bluebird, Bluebird is a rural noir suffused with the unique music, color, and nuance of East Texas.
Understanding “The Types of Cell Junctions” at Molecular Level. A Complete Pedagogy.
Understanding “The Types of Cell Junctions” at Molecular Level. A Complete Pedagogy. Cell junctions (or intercellular bridges) are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. Specialized cell junctions occur at points of cell-cell and cell-matrix contact in all tissues, and they are particularly plentiful in epithelia. Combined with cell adhesion molecules and extracellular matrix, cell junctions help hold animal cells together. Cell junctions are also especially important in enabling communication between neighboring cells via specialized protein ...
International Review of Cell and Molecular Biology
International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. - Authored by some of the foremost scientists in the field - Provides up-to-date information and directions for future research - Valuable reference material for advanced undergraduates, graduate students and professional scientists
Private Property Rights and the Environment
This book explores the current notion and definition of property, and its interpretation and implementation in relation to the environment. The author examines two primary problems: the degradation of land, natural resources and animal abuse; and the increasing erosion of private property rights from property owners by the arbitrary interference of state governments. Examining texts from antiquity to contemporary legislation, it portrays the historical development of the understanding of “nature” as “property” and discusses our obligations towards the environment. Drawing on the most influential political-philosophical texts from all periods of property rights history, the author analyzes modern national and international legislation and case law to offer legally-grounded evidence and explanations. This book advocates the incorporation of a formula that guarantees the protection of property rights into the legal system, and imposes clear and effective responsibility on property owners to limit the use of natural resources and the abuse of animals. This book will appeal to practitioners, researchers and students with an interest in environmental and private property law.
Country Life
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Heaven, My Home
In this "captivating" crime novel (People), Texas Ranger Darren Mathews is on the hunt for a missing child -- but it's the boy's family of white supremacists who are his real target. 9-year-old Levi King knew he should have left for home sooner; now he's alone in the darkness of vast Caddo Lake, in a boat whose motor just died. A sudden noise distracts him - and all goes dark. Darren Mathews is trying to emerge from another kind of darkness; after the events of his previous investigation, his marriage is in a precarious state of re-building, and his career and reputation lie in the hands of his mother, who's never exactly had his best interests at heart. Now she holds the key to his freedom,...
Gap Junction Structure and Chemical Regulation
Gap Junction Structure and Chemical Regulation: Direct Calmodulin Role in Cell-to-Cell Channel Gating describes and discusses the findings of major studies conducted during the past century on the structure and chemical regulation of direct cell-to-cell communication via gap junction channels. Chapters bring together important findings on direct cell communication, from its history, to its structure and regulation. These channels are essential for normal organ function, and mutations in their protein (connexin) cause various diseases. The book is useful for established investigators who need a review on the field and young investigators who need a thorough resource for study and comprehension. - Contains comprehensive, historical coverage on direct cell-to-cell communication - Provides detailed coverage of gap junction channel structure and regulation, with extensive coverage of the direct role of calmodulin in channel gating - Delivers a thorough description of models proposed for the chemical gating of gap junction channels
