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Tumor Microenvironment
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The rea...
Glossop Fire Station
Story based on the recollections of Fireman Peter Lee.
Tumor Microenvironment
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The rea...
Reaper Force - Inside Britain's Drone Wars
This unique insight into RAF Reaper operations in Afghanistan, Iraq and Syria is based on unprecedented research access to the Reaper squadrons and personnel at RAF Waddington in Lincolnshire and Creech Air Force Base in Nevada, USA. The author has observed lethal missile strikes against Islamic State jihadists in Syria and Iraq alongside the crews involved. He has also conducted extensive interviews with Reaper pilots, sensor operators, mission intelligence coordinators, and spouses and partners. The result is an intimate portrait of the human aspect of remote air warfare in the twenty-first century.
Changing Journalism
Journalism is in transition. Irrevocable decisions are being made, often based on flimsy evidence, which could change not only the future of journalism, but also the future of democracy. This book, based on extensive research, provides the opportunity to reflect upon these decisions and considers how journalism could change for the better and for the good of democracy. It covers: the business landscape work and employment the regulatory framework audiences and interaction the impact of technology on practices and content ethics in a converged world The book analyses research in both national and local journalism, broadcast, newspaper and online journalism, broadsheet and tabloid, drawing comparisons between the different outlets in the field of news journalism, making this essential reading for scholars and students of journalism and media studies.
Innovation in Small Construction Firms
Presenting new theoretical and practical insights and models grounded in descriptive case studies, Innovation in Small Construction Firms promotes the benefits of innovation within and between small and medium sized (SMEs) construction firms.
Measuring Immunity
Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology. * Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity* Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques * Includes basic science foundations as well as the approaches currently applied
Debates in History Teaching
Now in its second edition, Debates in History Teaching remains at the cutting edge of history education. It has been fully updated to take into account the latest developments in policy, research and professional practice. With further exploration into the major issues that history teachers encounter in their daily professional lives, it provides fresh guidance for thinking and practice for teachers within the UK and beyond. Written by a range of experts in history education, chapters cover all the key issues needed for clear thinking and excellent professional action. This book will enable you to reach informed judgements and argue your point of view with deeper theoretical knowledge and un...
Biology and Control Theory: Current Challenges
Creating some links between control feedback and biology modeling communities based on similarities in modeling, observing and perceiving alive structures, and analyzing interconnections between biological structures and subsystems was the main objective of this volume. In this context, biology systems need appropriate analysis tools due to their structure and hierarchy, complexity and environment interference, and we believe that these aspects may generate interesting research topics in control area. Indeed, several works, raising the potential impact of control developments to bring some beginning of answers in the context of biological systems, have been published in the recent years. The idea of this book was conceived in the context mentioned above with the objective to help in claiming many of the problems for control researchers, starting discussions and opening interactive debates between the control and biology communities, and, finally, to alert graduate students to the many interesting ideas at the frontier between control feedback theory and biology.
Analyzing T Cell Responses
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer vaccine strategy, a surrogate immunological end-point that correlates with clinical outcome needs to be defined, since it would facilitate the rapid comparison of these various formulations. Traditional immunological assays such as ELISA, proliferation and cytotoxicity assays can detect immune responses in vaccinated...
