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This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.
Neurovascular diseases and conditions, and their associated risk factors, represent a significant cause of cognitive disability in the United States and throughout the world. In the USA alone there are 750,000 new strokes each year, representing the number one cause of disability in the country. Hypertension, found in approximately 50 million Americans, has been shown to be associated with alterations of cognitive function, even in the absence of stroke and dementia. Recent studies of neurovascular disease have now revealed that neuropsychological function may be a more sensitive measure of brain integrity than coordination, motor or sensory function and correlates will with functional outcome measures. Neurovascular Neuropsychology focuses on focal and diffuse neurovascular disease in addition to systemic conditions in which cognition and behavior have been uniquely associated with different pathologic states. With an increasing number of patients being treated by healthcare professionals, Neurovascular Neuropsychology will prove to be a strong reference to consult in regards to neuropsychological syndromes.
It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer’s Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opport...
Captures the stories behind the work of the clinicians and scholars who have contributed significantly to neuropsychology's development.
This book reviews the neuropsychology of common and a few rare neurodegenerative conditions. The mild cognitive impairment prodrome of each condition is highlighted. Chapters include an autopsy-confirmed case presentation from the authors' files, current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging, associated clinical features, differential neuropsychological features and possible interventions.
A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.
Roughly one of every three Americans has some form of cardiovascular disease (CVD), including more than 70% of persons older than 75 years of age. Long associated with increased risk for mortality and disability, CVD is also a major risk factor for stroke and cerebrovascular disease. There has been growing consensus that CVD is also an important contributor to poor neurocognitive outcome in own right. Numerous studies now link CVD to accelerated cognitive decline, and structural and functional brain abnormalities, including neurodegnerative conditions in the elderly. While vascular dementia is the most obvious example of severe brain dysfunction directly tied to chronic vascular disease, evi...
This edited collection provides deep insights and varied perspectives of innovative and courageous efforts to reconcile the conflicts that have characterized the history of Indigenous people, settlers, and their descendants in Canada. From the opening chapter, the volume contextualizes why Canada is on a reconciliation journey, and how that journey is far from over. It is a multi-disciplinary treatise on decolonization, peacebuilding, and conflict transformation that is a must-read for those scholars, students, and practitioners of peacebuilding seeking a deeper understanding of reconciliation, decolonization, and community-building. Indigenous and non-Indigenous scholars and influencers from across Canada describe positive conflict transformation through various lenses, including education, economics, business, land sharing, and justice reform. The authors describe their personal and professional journeys, offering insights and research into how individuals and institutions are responding to reconciliation. Each chapter provides readers with windows into the tangible ways that Canadians are building a peaceful shared future, together.
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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and most westernized nations. Both CVDs and their risk factors confer substantial risk for stroke and dementia, but are also associated with more subtle changes in brain structure and function and cognitive performance prior to such devastating clinical outcomes. It has been suggested that there exists a continuum of brain abnormalities and cognitive difficulties associated with increasingly severe manifestations of cardiovascular risk factors and diseases that precede vascular cognitive impairment and may ultimately culminate in stroke or dementia. This second edition examines the relations of ...