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Imaging in Drug Discovery and Early Clinical Trials
This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.
Annual Report
None
Is There Life After Death?
People have believed in the existence of life after death throughout human history and in all regions of the world. Mere belief, however, does not make it true. What is the empirical evidence for life after death? Has any significant research been conducted, and if so, what conclusions does it suggest? In fact there exists a large body of research on topics relevant to the question of life after death. This book objectively examines that research, drawing together the observations of social science regarding such phenomena as reincarnation, near-death experiences, deathbed visions, cases of possession by dead spirits, and apparitions of the deceased. It considers possibilities including survival of consciousness and survival of personality, and reflects on the logical problems inherent in any model of postmortem survival. An extensive bibliography lists hundreds of studies of life-after-death phenomena.
Computational Neuroanatomy
In Computational Neuroanatomy: Principles and Methods, the path-breaking investigators who founded the field review the principles and key techniques available to begin the creation of anatomically accurate and complete models of the brain. Combining the vast, data-rich field of anatomy with the computational power of novel hardware, software, and computer graphics, these pioneering investigators lead the reader from the subcellular details of dendritic branching and firing to system-level assemblies and models.
Foreign Service List ...
List for March 7, 1844, is the list for September 10, 1842, amended in manuscript.
Suicide Prevention
This study presents an evaluation of the past, present and future of suicidal behaviour and efforts to prevent or facilitate suicide. Authors from the varying disciplines of psychology, sociology and psychiatry analyze suicide in the opening chapters. Through the exploration of the roles of these disciplines, the roles of primary physicians, and the impact of suicide prevention education in schools, the contributors describe the history of suicidology and the changes necessary for improvement. The book concludes with a section detailing the goals and activities of organizations designed to prevent or facilitate suicide.
Toxins and Signal Transduction
Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage...
Brown on Brown
Common conceptions permeating U.S. ethnic queer theory tend to confuse aesthetics with real-world acts and politics. Often Chicano/a representations of gay and lesbian experiences in literature and film are analyzed simply as propaganda. The cognitive, emotional, and narrational ingredients (that is, the subject matter and the formal traits) of those representations are frequently reduced to a priori agendas that emphasize a politics of difference. In this book, Frederick Luis Aldama follows an entirely different approach. He investigates the ways in which race and gay/lesbian sexuality intersect and operate in Chicano/a literature and film while taking into full account their imaginative na...
On Multiple Selves
On Multiple Selves refutes the idea that a human being has a single unified self. Instead, David Lester argues, the mind is made up of multiple selves, and this is a normal psychological phenomenon. Lester expands on his earlier work on the phenomenon, illuminating how a "multiple-self theory of the mind" is critically necessary to understanding human behavior. Most of us are aware that we have multiple selves. We adopt different "facade selves" depending on whom we are with. Lester argues that contrary to the popular psychological term, "false self," these presentations of self are all part of us, not false; they simply cover layers of identity. He asserts that at any given moment in time, ...
