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This work contains refereed papers presented at an interdisciplinary scientific meeting attended by a mix of leading biochemists and computer scientists held at DIMACS in March 1995. It describes the development of a variety of new methods which are being developed for attacking the important problem of molecular structure. It is intended for graduate students and researchers in numerical analysis, molecular biology, biochemistry, computer science, engineering, and operations.
Advances in Cancer Research
While the field of computational structural biology or structural bioinformatics is rapidly developing, there are few books with a relatively complete coverage of such diverse research subjects studied in the field as X-ray crystallography computing, NMR structure determination, potential energy minimization, dynamics simulation, and knowledge-based modeling. This book helps fill the gap by providing such a survey on all the related subjects. Comprising a collection of lecture notes for a computational structural biology course for the Program on Bioinformatics and Computational Biology at Iowa State University, the book is in essence a comprehensive summary of computational structural biology based on the author's own extensive research experience, and a review of the subject from the perspective of a computer scientist or applied mathematician. Readers will gain a deeper appreciation of the biological importance and mathematical novelty of the research in the field.
The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325, 329, and 332) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in the above-mentioned aspects of cell biology at the molecular level.
Cornell University has stood at the forefront of writing instruction, at least since the publication of William Strunk and E. B. White's classic, The Elements of Style, in 1918. For the past thirty years Cornell has been the site of a remarkably sustained and successful interdisciplinary approach to writing across the curriculum - a program that now coordinates nearly two hundred courses each semester sponsored by over thirty different departments.Local Knowledges, Local Practices provides an overview of Cornell's rich history and distinguished achievements in training students to write well. Including the views of professors representing a variety of disciplines - from animal science to political science, anthropology to philosophy, romance studies to neurobiology - this collection will serve as a resource for anyone interested in broadly conceived, discipline-specific writing instruction.
With contributions by specialists in optimization and practitioners in the fields of aerospace engineering, chemical engineering, and fluid and solid mechanics, the major themes include an assessment of the state of the art in optimization algorithms as well as challenging applications in design and control, in the areas of process engineering and systems with partial differential equation models.
This book will present the papers delivered at the first U.S. conference devoted exclusively to global optimization and will thus provide valuable insights into the significant research on the topic that has been emerging during recent years. Held at Princeton University in May 1991, the conference brought together an interdisciplinary group of the most active developers of algorithms for global optimization in order to focus the attention of the mathematical programming community on the unsolved problems and diverse applications of this field. The main subjects addressed at the conference were advances in deterministic and stochastic methods for global optimization, parallel algorithms for ...
This book examines the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets. It reviews what is known about STAR proteins and human disease.
Experimental science is a complicated creature. At the head there is a Gordian knot of ideas and hypotheses; behind is the accumulated mass of decades of research. Only the laboratory methods, the legs which propel science forward, remain firmly in touch with the ground. Growth, however is uneven; dinosaurs develop by solid means to give a vast body of results, but few ideas. Others sprint briefly to success with brilliant, though ill-supported, ideas. The problems which this book addresses is to maintain an organic unity between new ideas and the current profusion of innovative experimental tools. Only then can we have the framework on which our research thoughts may flourish. The contribut...
In the past two decades, breakthroughs in computer technology have made a tremendous impact on optimization. In particular, availability of parallel computers has created substantial interest in exploring the use of parallel processing for solving discrete and global optimization problems. The chapters in this volume cover a broad spectrum of recent research in parallel processing of discrete and related problems. The topics discussed include distributed branch-and-bound algorithms, parallel genetic algorithms for large scale discrete problems, simulated annealing, parallel branch-and-bound search under limited-memory constraints, parallelization of greedy randomized adaptive search procedures, parallel optical models of computing, randomized parallel algorithms, general techniques for the design of parallel discrete algorithms, parallel algorithms for the solution of quadratic assignment and satisfiability problems. The book will be a valuable source of information to faculty, students and researchers in combinatorial optimization and related areas.