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The Second Creation
The cloning of Dolly in 1996 from the cell of an adult sheep was a pivotal moment in history. For the first time, a team of scientists, led by Ian Wilmut and Keith Campbell, was able to clone a whole mammal using a single cultured adult body cell, a breakthrough that revolutionized three technologies--genetic engineering, genomics, and cloning by nuclear transfer from adult cells—and brought science ever closer to the possibility of human cloning. In this definitive account, the scientists who accomplished this stunning feat explain their hypotheses and experiments, their conclusions, and the ethical and scientific ramifications of their work. Written with award-winning science writer Colin Tudge, The Second Creation is a landmark work that details the most exciting and challenging scientific discovery of the twentieth century.
Developmental Biology Protocols
Developmental biology is one of the most exciting and fast-growing fields today. In part, this is so because the subject matter deals with the innately fascinating biological events—changes in form, structure, and function of the org- ism. The other reason for much of the excitement in developmental biology is that the field has truly become the unifying melting pot of biology, and provides a framework that integrates anatomy, physiology, genetics, biochemistry, and cellular and mole- lar biology, as well as evolutionary biology. No longer is the study of embryonic development merely “embryology.” In fact, development biology has produced - portant paradigms for both basic and clinical...
Experimental Approaches to Mammalian Embryonic Development
Recent advances in the experimental analysis of the mammalian embryo are discussed from various scientific perspectives in this summary of major breakthroughs in embryonic development.
A Clone of Your Own?
A Clone of Your Own? by Arlene Judith Klotzko takes a close look at the inevitability of cloning, and the ethical, legal, and philosophical issues surrounding it.
The Cloning Sourcebook
Animal cloning has developed quickly since the birth of Dolly the sheep. Yet many of the first questions to be raised still need to be answered. What do Dolly and her fellow mouse, cow, pig, goat and monkey clones mean for science? And for society? Why do so many people respond so fearfully to cloning? What are the ethical issues raised by cloning animals, and in the future, humans? How are the makers of public policy coping with the stunning fact that an entire animal can be reconstructed from a single adult cell? And that humans might well be next? The Cloning Source Book addresses all of these questions in a way that is unique in the cloning literature, by grounding what is effectively an...
The New York Times Book of Medicine
Today we live longer, healthier lives than ever before in history—a transformation due almost entirely to tremendous advances in medicine. This change is so profound, with many major illnesses nearly wiped out, that its hard now to imagine what the world was like in 1851, when the New York Times began publishing. Treatments for depression, blood pressure, heart disease, ulcers, and diabetes came later; antibiotics were nonexistent, viruses unheard of, and no one realized yet that DNA carried blueprints for life or the importance of stem cells. Edited by award-winning writer Gina Kolata, this eye-opening collection of 150 articles from the New York Times archive charts the developing scientific insights and breakthroughs into diagnosing and treating conditions like typhoid, tuberculosis, cancer, diabetes, Alzheimers, and AIDS, and chronicles the struggles to treat mental illness and the enormous success of vaccines. It also reveals medical mistakes, lapses in ethics, and wrong paths taken in hopes of curing disease. Every illness, every landmark has a tale, and the newspapers top reporters tell each one with perceptiveness and skill.
Manipulation of Mammalian Development
Developmental biology has been transformed recently by discoveries in the fields of molecular biology, cell biology, and immunology. New ways of manip ulating mammalian development are uncovering control mechanisms and ena bling us to apply them in solving practical problems in animal production and human health. This book outlines some of these new manipulations and how they have contributed to the present state of developmental biology. Chapter 1 describes gene transfer by micro injection of cloned recombinant DNA into zygotes. Although the factors that affect transformation frequencies and integration sites are still unknown, such techniques offer a number of exciting prospects. Research ...
Becoming Immortal
Providing the philosophical, practical, and theoretical leverage for abandoning evolution and development in favor of engineering human beings, Becoming Immortal examines the directions biological change might take if civilization were to take charge of its own destiny. With the aid of embryonic manipulation, cloning, and stem-cell therapy, immortality would seem within the reach of future generations. The question is, "Do we presently have the wisdom to undertake creating immortal organisms?" The author examines every facet of this question, from theory to practice, and provides an answer through an in-depth analysis of life and death.
Reproduction Reborn
A cutting-edge analysis of the global issues surrounding modern reproductive technologies Advances in assisted reproductive technologies have sparked global policy debates since the birth of the first so-called "test tube baby" in 1978. Today, mitochondrial replacement therapies represent the most recent advancement in assisted reproductive technologies, allowing some women with mitochondrial diseases to birth babies without those diseases. In the past decade, mitochondrial replacement therapies have captured public sentiment, reigniting debates around social views of reproductive rights and the appropriate legal and political response. Reproduction Reborn guides readers through the history ...
Protein Glycosylation
Protein Glycosylation provides clear, up-to-date, and integrated coverage of key topics in this field. Particular emphasis is placed on the biosynthetic pathways that result in a wide variety of identified protein-bound oligosaccharides. Protein Glycosylation begins with an overview of the chemical structures of mono- and oligosaccharides, to provide a scientific basis for the later chapters. The book includes discussions on the purification, function, and enzyme kinetics of selected glycosidases and glycotransferases, as well as a review of the roles of oligosaccharides in glycoprotein function and the in vivo role of glycoproteins themselves. Finally, the in vitro synthesis of glycoproteins is presented, together with future directions in glycobiology. Protein Glycosylation serves as an excellent text for upper-level undergraduate and graduate students as well as a reference for those scientists whose training is not in glycobiology but who are moving into this field.
