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Target Discovery and Validation Reviews and Protocols
These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.
Neuroendocrinology
Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes). - The best researchers in the field provide their conclusions in the context of the latest experimental results - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - Of great value for researchers and experts, but also for students as a background reference
Trends in Cellular Signaling
Cell signalling is the communication inside a cell or with its environment. It plays an important role in cellular growth, survival and apoptosis. For instance, the growth of a cell requires production of certain proteins. The genes that encode these proteins are located in DNA inside the nucleus while the initial signal for cellular growth may come from outside the cell. To induce the expression of these genes, the external signal must pass through specific pathways to reach these genes in DNA. The signalling pathway involves several proteins. If any one of them becomes abnormal or non-functional, the cellular process would be altered, which may cause disease. Therefore, knowing the detailed pathway is very important in understanding the pathogenesis of diseases.
Engineering in Translational Medicine
This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for sc...
Female Urinary Tract Infections in Clinical Practice
This book comprehensively covers the latest consensus in the diagnosis and management of patients with recurrent Urinary Tract Infections (UTIs). It features a broad overview of the basic science and the spread of antibiotic resistance in UTIs. Guidelines are provided on the recommended approaches for using antibiotics including dosage, duration, resistance rates for a range of antibiotics, and available methods for combating antibiotic resistance. Further topics covered include prophylaxis, including conservative lifestyle modifications as well as preventative therapies. Female Urinary Tract Infections in Clinical Practice summarises the basic science, use of antibiotics, and preventative strategies for UTIs and represents a timely and valuable resource for all practising and trainee medical professionals who encounter these patients in their practice.
Radiation And Thyroid Cancer
The considerable increase in the incidence of thyroid cancer in children in areas exposed to the fallout from the Chernobyl nuclear reactor accident has drawn attention to the need for a better understanding of the relationship between radiation exposure (especially from the radionuclides of iodine) and the risk of thyroid cancer. An increase in thyroid cancer has been reported both in patients exposed to therapeutic and diagnostic external radiation, and in the population exposed to radiation from the Hiroshima and Nagasaki atomic bombs. While there is no evidence of a significant increase of this cancer in patients treated with radioactive iodine, an increase in thyroid cancer incidence wa...
