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Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "regional" control is exerted by natural selection (essentially negative or purifying selection). A "neo-selectionist" model is proposed for genome evolution.· Summarizes the existing knowledge on genome organization and evolution in a self-containedbook· Discusses important open problem, without refraining from criticism wheneverappropriate
The book focuses on photonic devices and systems for space applications and critically reviews the most promising research advances in the field of photonic technologies, which may have a significant impact on the performance of space systems.Photonics is emerging as a crucial enabling technology having the potential of enhancing many space systems, including the links for on-board data handling, the high-resolution measurement systems, and the processing units. The book discusses this subject with a special emphasis on the new guided-wave devices with high performance, low cost and size.Most of the scientific content of the book is novel and it is devoted to academic and industrial researchers working on the field.
Includes section, "Recent book acquisitions" (varies: Recent United States publications) formerly published separately by the U.S. Army Medical Library.
One half-century later, the catastrophic ramming of the MS Stockholm into the Italian luxury liner the SS Andrea Doria in 1956 is relived in this candid, heartrending account. Author Pierette Domenica Simpson, who, with her grandparents, survived the tragedy off the shoals of Nantucket, shares the human and technical aspects of what has become known as the greatest sea rescue in history. As only an eyewitness can do, the author presents survivors' recollections in dramatic vignettes that meticulously re-create a horrific event-one that could have been another Titanic. Both poor immigrants and wealthy travelers give their accounts of ultimate despair and infinite elation after staring at their own reflections in the black ocean that night and seeing death stare back. Equally dramatic are the revelations of new facts exposed by nautical experts from two continents facts that solve the "mystery" of who was to blame for this most improbable collision between two ships on the open seas.
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Frank DeSario shares his almost forty year career in a vivid account of his experiences with the Boston Police department. The Mafia, the gangland slayings, the Combat Zone, bussing and the resulting racial issues and riots, the thugs and the corruption are all discussed with a first hand look at the events. Frank also shares the glamorous side of his job which included escorting high profile celebrities, religious leaders and political leaders during their visits to the Boston area. The photos are vivid but give the reader a close look at what it was like to be a cop in Boston during the last four decades. He proudly covets his #1 badge as a symbol of strength, integrity, honor and pride.
In the evolving environment of bioinformatics, genomics, and computational biology, academic scholars are facing a challenging challenge – keeping informed about the latest research trends and findings. With unprecedented advancements in sequencing technologies, computational algorithms, and machine learning, these fields have become indispensable tools for drug discovery, disease research, genome sequencing, and more. As scholars strive to decode the language of DNA, predict protein structures, and navigate the complexities of biological data analysis, the need for a comprehensive and up-to-date resource becomes paramount. The Research Anthology on Bioinformatics, Genomics, and Computatio...
This book is the first in-depth investigation of the Goth subculture in Italy, focusing in particular on the city of Milan. It grows out of a three year research project - the first in Italy of this scope on the topic - based on the life histories of two dozen participants. In light of this, Simone Tosoni and Emanuela Zuccalà propose an innovative approach to the study of spectacular subcultures: contrarily to the most common accounts of the spectacular subcultures of the 80s, this book describes the experience of subcultural belonging as plural and internally diversified. In particular, three different variations - or 'enactments' - of goth are described in-depth: the politically engaged o...