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Terapia Gênica com hPEDF via vetores AAVs e Nanopartículas na Asma Alérgica
A asma é uma doença inflamatória crônica que acomete os pulmões, muitas vezes associada a um processo de remodelamento com obstrução das vias aéreas e comprometimento da ventilação pulmonar. Até o momento, não há tratamento capaz de reverter ou minimizar tais alterações estruturais, sendo necessária a busca por novas estratégias terapêuticas. A terapia gênica surge como uma alternativa promissora para o tratamento de doenças respiratórias, pois o pulmão é um órgão de fácil acesso. O fator derivado do epitélio pigmentado (PEDF) possui atividades antiangiogênicas, anti-inflamatórias e antifibróticas e seria promissor para o tratamento de doenças inflamatórias que acometem os pulmões. Portanto, a terapia gênica com AAV8-hPEDF e PEG-PBAE-hPEDF é promissora para o tratamento da asma alérgica, fornecendo meios de reverter o remodelamento da asma e, potencialmente, outras doenças pulmonares que cursem com inflamação e fibrose.
Família Pires
O presente livro e o website Família Pires, disponível em fazem parte de uma iniciativa que visa ampliar e manter o trabalho de genealogia da Família Pires. Nessa perspectiva, os conteúdos e a organização deste empreendimento editorial têm os seguintes objetivos: • Mostrar a árvore genealógica dos Pires (Peres, na língua espanhola); • Ampliar a pesquisa genealógica dos Pires e parentes correlatos; • Compartilhar histórias da Família Pires; • Reunir, cada vez mais, os membros da Família, notícias e informações úteis; • Trabalhar com membros da Família para preservar e valorizar a história; • Compartilhar a pesquisa genealógica com outras pessoas; • Fornecer ...
Hyperhidrosis
Hyperhidrosis is a medical condition in which a person sweats excessively and unpredictably. People with hyperhidrosis may sweat even when the temperature is cool or when they are at rest. Despite prevalence of at least 1% of the global population, Hyperhidrosis is still an unknown entity, for the most part -- an undertreated and even neglected medical condition. Moreover, there are few sources summarizing the knowledge on hyperhidrosis to a wider audience. The purpose of this book is to provide information regarding hyperhidrosis, ranging from basic information on pathophysiology to the most advanced therapeutic alternatives. From a therapeutic perspective, hyperhidrosis requires clinical t...
Self Portrait in Green
'NDiaye is a hypnotic storyteller with an unflinching understanding of the rock-bottom reality of most people's life.' New York Times ' One of France's most exciting prose stylists.' The Guardian. Obsessed by her encounters with the mysterious green women, and haunted by the Garonne River, a nameless narrator seeks them out in La Roele, Paris, Marseille, and Ouagadougou. Each encounter reveals different aspects of the women; real or imagined, dead or alive, seductive or suicidal, driving the narrator deeper into her obsession, in this unsettling exploration of identity, memory and paranoia. Self Portrait in Green is the multi-prize winning, Marie NDiaye's brilliant subversion of the memoir. Written in diary entries, with lyrical prose and dreamlike imagery, we start with and return to the river, which mirrors the narrative by posing more questions than it answers.
Cellulose Nanoparticles Volume 1
Cellulose Nanoparticles: Chemistry and Fundamentals covers the synthesis, characterization and processing of cellulose nanomaterials.
Ancient South America
South America is still the least known continent in the world. Isolated for all of prehistory and much of its history, it is quite alien to the average European, Asian, or North American. Yet this continent witnessed the development of a series of cultures and of advanced civilizations which rival anything in Eurasia or Africa. Independently South American peoples invented agriculture and domesticated animals, pottery, elaborate architecture, and the arts of working metals. Tribes, chiefdoms, and immense conquest states rose, flourished, and disappeared leaving only their ruined monuments and broken artifacts as testimonials to past greatness. Ancient South America encompasses ten millennia of cultural development and diversity. Accessibly written and abundantly illustrated, this book will be enjoyed by students of archaeology, anthropology, and art history.
Framing Complexity in Formative Mesoamerica
A fresh examination of variable social and economic processes, Framing Complexity in Formative Mesoamerica explores nascent social complexity during the Preclassic/Formative period in Mesoamerica and addresses broader social questions about egalitarian and transegalitarian prehispanic Mesoamerican cultural groups. Contributors present multiple lines of evidence demonstrating the process of social complexity and reconsider a number of traditionally accepted models and presumed tenets as a result of the wealth of empirical data that has been gathered over the past four decades. Their chapters approach complexity as a process rather than a state of being by exploring social aggregation, the eme...
The Oxford Handbook of the Aztecs
The Oxford Handbook of the Aztecs, the first of its kind, provides a current overview of recent research on the Aztec empire, the best documented prehispanic society in the Americas. Chapters span from the establishment of Aztec city-states to the encounter with the Spanish empire and the Colonial period that shaped the modern world. Articles in the Handbook take up new research trends and methodologies and current debates. The Handbook articles are divided into seven parts. Part I, Archaeology of the Aztecs, introduces the Aztecs, as well as Aztec studies today, including the recent practice of archaeology, ethnohistory, museum studies, and conservation. The articles in Part II, Historical ...
