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The main objective of this book is to bring together multidisciplinary contributions from leading authorities on the properties and roles of water in cell systems which are otherwise dispersed in the literature and difficult to gather. The authors are drawn from areas of physics, chemistry, biology and physiology, where water plays a central role. The book focuses on current research and developments in the theoretical and experimental studies of water in biological systems and compounds, such as interaction with hydrophobic or hydrophilic structures, protein and membrane surfaces. It provides insights into the importance of water in cellular processes and physiology and, ultimately, in life, brain function, and health.
Intravoxel incoherent motion (IVIM) refers to translational movements which within a given voxel and during the measurement time present a distribution of speeds in orientation and/or amplitude. The concept was introduced in 1986 together with the foundation of diffusion MRI because it had been realized that flow of blood in capillaries (perfusion) would mimic a diffusion process and impact diffusion MRI measurements. IVIM-based perfusion MRI, which does not require injection of any tracer or contrast agent, has been first investigated in the brain, but is now experiencing a remarkable revival for applications throughout the body, especially for oncologic applications, from diagnosis to treatment monitoring. This book addresses a number of highly topical aspects of the field from leading authorities, introducing the concepts behind IVIM MRI, outlining related methodological issues, and summarizing its current usage and potential for clinical applications. It also presents future research directions, both in terms of methodological development and clinical application fields, extending to new, non-perfusion applications of IVIM MRI, such as virtual MR elastography.
This exciting book describes the latest technology in non-invasive thermometry that measures temperature distribution, with discussions focusing on image-based techniques. This is the first book devoted entirely to this topic. An international team of experts detail all important techniques for possible non-invasive thermometry. Descriptions of each technique explain in depth the principles of measurement, the measurement system, obtained temperature image, and the future prospects for the method.
This book provides a concise overview of emerging technologies in the field of modern neuroimaging. Fundamental principles of the main imaging modalities are described as well as advanced imaging techniqes including diffusion weighted imaging, perfusion imaging, arterial spin labeling, diffusion tensor imaging, intravoxel incoherent motion, MR spectroscopy, functional MRI, and artificial intelligence. The physical concepts underlying each imaging technique are carefully and clearly explained in a way suited to a medical audience without prior technical knowledge. In addition, the clinical applications of the various techniques are described with the aid of illustrative clinical examples. Helpful background information is also presented on the core principles of MRI and the evolution of neuroimaging, and important references to current medical research are highlighted. The book will meet the needs of a range of non-technological professionals with an interest in advanced neuroimaging, including radiology researchers and clinicians in the fields of neurology, neurosurgery, and psychiatry.
This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into ...
This book constitutes the refeered proceedings of the 21st International Conference on Information Processing in Medical Imaging, IPMI 2009, held in Williamsburg, VA, USA, in July 2009 The 26 revised full papers and 33 revised poster papers presented were carefully reviewed and selected from 150 submissions. The papers are organized in topical sections on diffusion imaging, PET imaging, image registration, functional networks, space curves, tractography, microscopy, exploratory analyses, features and detection, image guided surgery, shape analysis, motion, and segmentation and validation.
Professor Derek Jones, a world authority on diffusion MRI, has assembled most of the world's leading scientists and clinicians developing and applying diffusion MRI to produce an authorship list that reads like a "Who's Who" of the field and an essential resource for those working with diffusion MRI. Destined to be a modern classic, this definitive and richly illustrated work covers all aspects of diffusion MRI from basic theory to clinical application. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
The remarkable story of how today's brain scanning techniques were developed, told by one of the field's pioneers It is now possible to witness human brain activity while we are talking, reading, or thinking, thanks to revolutionary neuroimaging techniques like magnetic resonance imaging (MRI). These groundbreaking advances have opened infinite fields of investigation—into such areas as musical perception, brain development in utero, and faulty brain connections leading to psychiatric disorders—and have raised unprecedented ethical issues. In Looking Inside the Brain, one of the leading pioneers of the field, Denis Le Bihan, offers an engaging account of the sophisticated interdisciplina...
Collected works of a noted Pakistani poet, particularly songs without musical notation.