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Amyotrophic Lateral Sclerosis
ALS, also known as Lou Gehrig's Disease, is the most common of the motor neuron diseases that cause muscle atrophy. ALS is a chronic, progressively debilitating disease characterised by progressive muscle atrophy starting in the limbs and spreading to the rest of the body, often accompanied by overactive reflexes. It usually manifests itself after the age of 40. The exact cause of ALS is unknown and there is no cure at this time. ALS may be fatal in one year or continue for 10 or more years. This new book includes leading edge research from around the world and covers the aetiology, pathogenesis, symptoms, diagnosis, and treatment of amyotrophic lateral sclerosis (ALS).
Mechanisms and Emerging Therapies in Tremor Disorders
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
Neurocutaneous Disorders
The book provides an authoritative source of knowledge about these problematic disorders. It bridges the gap between clinical recognition and the new molecular medicine. The editors, distinguished clinicians and geneticists, assembled an internationally renowned group of collaborators, many of them the experts who first described a particular disorder or established its present accepted definition. They have written a practical, comprehensive guide to the recognition, investigation and management of more than 60 recognised phakomatoses.
Occupational and Environmental Lung Disease
This Monograph provides the general respiratory physician with a working reference based on the latest literature and expert opinion. The initial chapter provides a contemporaneous global perspective of the epidemiology of occupational and environmental lung diseases in an ever-evolving landscape. The book then goes on to consider specific occupational lung diseases. Each chapters has a clear clinical focus and considers: key questions to ask in the history; appropriate investigations to undertake; differential diagnoses; and management. Controversies or diagnostic conundrums encountered in the clinic are also considered, and further chapters are more broadly centred on the non-workplace environment; specifically, the respiratory symptoms and diseases associated with both the outdoor and indoor environments.
The Polus Family of Green Lake and Marquette Counties, Wisconsin 1771-2009
This is a genealogical listing of the descendants of the Polus family in Green Lake and Marquette Counties, Wisconsin.
I Kill Monsters
Mikkel and Szandor kill monsters. They're not government funded, they're not from a time-honored lineage of hunters, nor are they rich kids with lots of toys. They're two twenty-something brothers from the poor side of town who have taken it on themselves to rid the streets and underground of creatures who would prey on the innocent. Donning gas masks and using makeshift weaponry, they delve into the labyrinthine sewer system of New Avalon to grapple with snarling zombies, flesh-eating ghouls, insectoid hive creatures, and more. It's a dirty job and it rarely pays, but someone has to do it. Hired by a woman from the rich side of town who believes she's being stalked by monsters, the two brothers think they've finally gotten an easy job that will pay well. But as they follow the clues, things are not adding up. Kidnappings, jackbooted commandos, and mysterious emails are just the beginning. Soon they find themselves involved in something bigger than monsters. It's anybody's guess whether they'll come through it alive, much less get paid. I Kill Monsters is an exciting punk rock urban fantasy for those who enjoy their protagonists with a mouth on them and a weapon in their hands.
Occupational Asthma
Recent developments in occupational asthma research and clinical practice are the focus of this publication. It discusses the contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults, powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures, and diagnostic criteria for work related and work aggravated asthma. Specific emphasis is given to exposure response relationships for allergen exposure, large gene-environment studies and whole genome screening approaches. Management, prevention and surveillance are covered as well. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes. Issues in the design of population studies are discussed to assist the readers in designing and conducting their own study. This comprehensive volume presents new developments changing the occupational asthma field in the coming years.
Medicine Science and Dreams
Physician-scientists are unusual creatures. While we are drawn to the clinical challenges of our patients, we are also drawn to the opportunities that our patients’ medical problems bring to science. This book contains the unique experiences and encounters that drew 20 accomplished physician-scientists to this profession. These personal stories are those of people and circumstances that have had profound effects on our career decisions, our creative opportunities, and our lives. These stories also serve to highlight the lessons learned along the way and the distinct attributes of these women and men of medicine and science. Our combined hope is that our collective biographies will enhance ...
