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Management of Myocardial Reperfusion Injury
Much has been written about reperfusion injury in the past decade but unfortunately the information has been generally presented in the form of original specialist papers and little if any integral publication exists on the topic, summarising and analysing the clinical impact of the condition and its management. The pathophysiology and molecular mechanisms of reperfusion injury are complex and, regarding diagnosis, individual diagnostic techniques have been proposed but without a proper assessment of the relative values of these methods. A publication dealing with integral diagnostic strategies would be welcome by the managing physician. Management of the condition is also problematic, as strategies that appear to work in the experimental models do not translate into beneficial interventions in patients. There is a need for these issues to be addressed and discussed in a monographic fashion. Management of Myocardial Reperfusion Injury will tackle these issues in a modern and systematic way and the information will be delivered in a fashion that will be appealing to the reader.
AHA Scientific Sessions 2019 - Final Program
The American Heart Association’s Scientific Sessions 2019 is bringing big science, big technology, and big networking opportunities to Philadelphia, Pennsylvania this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
Cardiac Diseases
This is the latest book in a series of cardiovascular-related texts from IntechOpen Publishing. The present volume considers general aspects of cardiac disease and is divided into three distinct sections covering cardiac risk, cardiorenal pathology, and novel interventional surgical techniques. The chapters offer insight into the current state of the art with respect to the risks of developing cardiovascular diseases, maintenance of patent vascular access in patients with the cardiorenal syndrome, and a plethora of novel interventional technologies all aimed at salvaging damaged tissue and improving prognosis and reducing mortality. This volume of 18 chapters is intended for general medical and biomedical students at both undergraduate and postgraduate level. It also offers insightful updates on recent advances in the understanding of the pathophysiology of cardiac diseases and the new techniques added to the medical armamentarium to improve the outcomes and prevent mortality and would be of interest to those working in academia and healthcare science.
Primary Angioplasty
This book is open access under a CC BY 4.0 license. This quick-reference handbook offers a concise and practical review of key aspects of the treatment of ST-segment elevation myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention (PPCI). In the context of STEMI, PPCI is the preferred mode of emergency revascularization. Access to PPCI is rapidly increasing and is now routinely practiced in both general and specialist hospitals and there has been a recent emphasis on developing STEMI networks to enhance and expedite the referral pathway. This coupled with concurrent developments to enhance the safety and efficacy of the PPCI procedure has heralded an era where...
Pharmacology of Mitochondria
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.
Nanophytomedicine
Nanophytomedicine is a branch of medicine that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology and the use of phytonanoparticles for biomedical applications. Nanophytomedicine covers recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. This book assesses the recent advancements and applications of plant-based nanoparticles and also highlights emerging concepts of biomimetics. The book contains 24 chapters encompassing various therapeutic applications of phytochemicals derived from plants, ferns, seaweeds, and so on, mediated through nanotechnology and its allied approaches. A fervent attempt has been made to compile every significant advancement in the field of phytonanomedicine so as to accelerate its momentum in the pharmaceutical sector.
Pathobiochemistry of Metabolic Disorders
Pathobiochemistry means biochemistry of disease. In the curriculum of medical studies it may serve as a useful and highly enjoyable “bridge” between the basic science of the first years, and the clinical training later. Practical limitations dictate that from a vast area of human pathology a careful selection of topics must be made. The eleven chapters of this book deal with the basics of acid-base balance disorders, inflammation, reactive oxygen species and antioxidant defense, non-enzymatic glycations, atherosclerosis, metabolic syndrome, ischemia/reperfusion of the heart, protein misfolding disorders, ageing, and consequences of alcohol abuse. The selection covers some pathogenetic processes behind several important medical problems of the present. Further, it more or less implicitly points to the inner causes of diseases. The inner maintenance of body structural and chemical integrity is costly and has its limits that regularly get exceeded, which is the ultimate reason for ageing and contributes to many, often also age-related, civilization diseases.
Innate Tolerance in the CNS
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for precon...
Role of Mitochondrial Quality Control in Myocardial and Microvascular Physiology and Pathophysiology
The heart is a strong muscular pump that enables tissue and organ perfusion. Therefore, a continuous supply of fresh blood is vital for cardiac function. In coronary artery disease, plaques or thrombi induce rapid occlusion, which restricts blood flow to the heart. The primary effect of coronary artery disease is substantial cardiomyocyte death, which prevents the heart from effectively pumping blood to vital organs.
