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Alternatives To Animal Testing
Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries.
Addcon World 2005
None
Practical Guide to Chemical Safety Testing
Annotation This book describes the different tests that must be performed on new chemicals and other materials to demonstrate to the regulatory authorities that they are safe for use. Tests vary from physico-chemical, measuring properties such as melting point and density, through genetic toxicity studies, to mammalian toxicology and studies to investigate effects on the environment. This book describes clearly the process of obtaining approval for use in a variety of global regions and across different applications. It also explains why different tests are performed and the implications of the results.
Nucleating Agents
A very important factor in obtaining optimised physical properties from a semi-crystalline polymer is the size of the crystalline structures present in the material, and this crucially depends on the initiation process of crystallisation of the polymer from the melt - nucleation. This review provides information on the development of materials and methods for influencing the nucleation of polymer crystallisation in commercial processing by means of addition of low levels of adjuvants specifically selected for this purpose.
Bonding Elastomers
This review has been written as a practical approach to bonding various kinds of elastomers to substrates such as steel and plastics, as used in the manufacture of diverse products such as rubber covered rolls, urethane fork lift wheels, rubber lining for chemical storage or solid rocket motors, engine bushes and mounts, seals for transmissions, electrical power connectors and military tank track pads. Based on the authors' years of experience working closely with end-use customers and it offers a thorough overview of how to successfully bond rubber to a given substrate in the manufacture of quality rubber engineered components. This review is supported by an indexed section containing several hundred key references and abstracts selected from the Rapra Abstracts database.
Risk reduction
Concerned with the need to reduce chemical risks, this text also covers related biological and physical risks. Risk reduction has an important economic role, not least in developing countries. Many of the contributors are from develping countries and indicate the problems and some of the solutions their countries will need to adopt during their process of reconstruction, development and recovery. The text discusses the decision-making process involving the political, socioeconomic, engineering, and natural sciences so as to develop, analyze and compare regulatory options. It considers how such measured decision making enables the selection of optimal responses to achieve safety from perceived hazards.
Epoxy Composites
None
Biocides in Plastics
This Rapra Review Report examines the use of biocides in plastics with reference to material types and application requirements. The commonly available biocides are reviewed and details of their strengths and weaknesses are provided. The author reviews the frequently used test methods for fungi and bacteria, and, in an ever-changing regulatory environment, explores the influence of legislation on the current and future use of such biocides. This detailed and state-of-the-art review is supported by an indexed section containing several hundred key references and abstracts selected from the Polymer Library database.
Fluoroplastics
Fluoropolymers were discovered accidentally by Plunkett in 1938. He was working on freon and accidentally polymerised tetrafluoroethylene. The result was polytetrafluoroethylene (PTFE), more commonly known as Teflon. PTFE is inert to virtually all chemicals and is considered to be the most slippery material in existence - it has the lowest coefficient of friction of any known solid material. These properties have made it one of the most valuable and versatile technologies ever invented, contributing to significant advancements in areas such as aerospace, communications, electronics, industrial.
Cancer Risk Assessment
With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.
