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Beta-Catenin and Ha-ras - Master Regulators of Zonal Gene Expression in Mouse Liver?
Hepatocytes located in the periportal or perivenous regions of the liver lobule have different, often complementary functions, as indicated by differences in the content and activity of various enzymes of the intermediary and xenobiotic metabolism. The signaling molecules mediating this metabolic zonation, however, are largely unknown. Based on the correlation of marker protein expression between perivenous hepatocytes and Ctnnb1 (encoding beta-catenin)-mutated mouse hepatomas and between periportal hepatocytes and Ha-ras-mutated hepatomas, a hypothesis was developed postulating that two opposing signals, a Wnt-signal maybe delivered by endothelial cells of the central veins activating a bet...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Information Resources in Toxicology
This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the "hot topi...
