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Beta-Catenin and Ha-ras - Master Regulators of Zonal Gene Expression in Mouse Liver?
Hepatocytes located in the periportal or perivenous regions of the liver lobule have different, often complementary functions, as indicated by differences in the content and activity of various enzymes of the intermediary and xenobiotic metabolism. The signaling molecules mediating this metabolic zonation, however, are largely unknown. Based on the correlation of marker protein expression between perivenous hepatocytes and Ctnnb1 (encoding beta-catenin)-mutated mouse hepatomas and between periportal hepatocytes and Ha-ras-mutated hepatomas, a hypothesis was developed postulating that two opposing signals, a Wnt-signal maybe delivered by endothelial cells of the central veins activating a bet...
European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment
The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.
Connexine, Zellverbindungen und der Rezeptor c-Met in der Murinen Hepatokanzerogenese
Krebserkrankungen sind die zweithaufigste Todesursache in Deutschland. Sie verursachen nicht nur extremes Leid fur die Betroffenen, sondern auch immense Gesundheitskosten. Molekulare Mechanismen der Krebsentstehung aufzuklaren und somit die Basis fur potentielle neue Tumortherapien zu schaffen, sollte daher ein vorrangiges Ziel biomedizinischer Forschung sein. Unter den Krebserkrankungen ist das Hepatozellulare Karzinom (HCC) mit rund 600000 Neuerkrankungen pro Jahr weltweit eine der haufigsten. Die vorliegende Arbeit beschaftigt sich mit verschiedenen Proteinen, die bei der Entstehung von Hepatozellularen Karzinomen von Bedeutung sind. Dabei geht es unter anderem um eine Gruppe von Proteine...
Traditional Medicines in Drug Discovery and Development
This comprehensive book, comprising 20 chapters contributed by respected academics in their respective fields, highlights the immense contribution of traditional medicine to the discovery and development of modern drugs. Each chapter provides in-depth details, stimulating experts to further explore the flora used in traditional medicines and inspiring younger investigators to delve into the mysterious world of secondary metabolites in their quest for novel molecules. This book is of immense value to scientists, academicians, researchers, and students alike, making it a valuable addition to personal collections and libraries.
21st Century Nanoscience – A Handbook
This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This eighth volume in a ten-volume set covers nanopharmaceuticals, nanomedicine, and food nanoscience. Key Features: Provides the most compr...
21st Century Nanoscience
This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics, by the same editor, published in the fall of 2010, was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in th...
Food Applications of Nanotechnology
Nanotechnology has developed remarkably in recent years and, applied in the food industry, has allowed new industrial advances, the improvement of conventional technologies, and the commercialization of products with new features and functionalities. This progress offers the potential to increase productivity for producers, food security for consumers and economic growth for industries. Food Applications of Nanotechnology presents the main advances of nanotechnology for food industry development. The fundamental concepts of the technique are presented, followed by examples of application in several sectors, such as the enhancement of flavor, color and sensory characteristics; the description...
