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Designed for graduate and advanced undergraduate courses, this book goes beyond the simple analysis of naming a drug or toxin, taking a mechanistic approach to their effects on the body. It provides an understanding of the mechanisms of action of drugs and toxins as well as their physiologic and pathologic consequences on the affected organ system. Case histories, photographs of gross pathology, and photomicrographs further illustrate the processes and effects of toxic substances on the body.
A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best potential of succeeding urine as the next matrix of choice for drug detection, four popular saliva testing devices are examined: Intercept®, the Drager Drug Test®, Oratect®, and Drugwipe. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.
Herbal Products: Toxicology and Clinical Pharmacology, Second Edition builds on the informative foundation laid by its predecessor. This fully revised and expanded second edition boasts more than 200 new references that document efficacy studies and adverse effects and four new chapters devoted to dietary products. Practitioners and researchers will find that this volume is a comprehensive resource for objective clinical information.
Sudden in-custody restraint deaths have emerged as a critical and imp- tant problem for police, correctional, and medical care workers. The scope and magnitude of the problem clearly reveals that the subject matter is worthy of further consideration. Although the frequency of these deaths is very low, the criticality of its occurrence requires attention to the subject matter. The purpose of Sudden Deaths in Custody is to provide current information that addresses the issue from a number of perspectives. It is our purpose to assemble, under one title, current research that addresses the varying facets that underscore the nature of sudden in-custody deaths. The intent is to provide information...
In this revised and expanded edition, leading forensic scientist John Trestrail offers a pioneering survey of all that is known about the use of poison as a weapon in murder. Topics range from the use of poisons in history and literature to convicting the poisoner in court, and include a review of the different types of poisons, techniques for crime scene investigation, and the critical essentials of the forensic autopsy. The author updates what is currently known about poisoners in general and their victims. The Appendix has been updated to include the more commonly used poisons, as well as the use of antifreeze as a poison.
Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media. This book provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today. Chapters focus specifically on the application of these practices to drugs of abuse. The up-to-date information provided is complemented with thorough references.