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Vitamins and Hormones
Vitamins and Hormones
Carotenoids
0. ISLER Chemical Research Department, F. Hoffmann-LaRoche&Co. Ltd., Basle, Switzerland A. General Remarks . . . 12 B. Historical Development 13 C. Scope and Limitations 15 D. Vitamins A and Provitamins A . 15 E. Carotenoids as Natural Colouring Matters . 19 F. Other Natural Pigments and Related Compounds. 21 G. Nomenclature . . . 22 H. Lists of Carotenoids 24 I. Acknowledgments 25 References . . . . . . 25 0. ISLER 12 A. General Remarks The brightly coloured carotenoid pigments have aroused the curiosity of scientists since the beginning of organic chemistry. Indeed some of the oldest studies were published during the early 19th century. Research on carotenoids can be separated into four br...
Progress in Drug Research
Hepatitis C virus (HCV) was first identified in 1989 as the etiologic agent of non-A, non-B hepatitis [1] and is currently recognized as the leading cause of chronic liver disease worldwide. In contrast to hepatitis B virus infection, in which only about 5% of adult infections become chronic, more than 80% of HCV-infected patients develop chronic hepatitis. Moreover, 20-50% of those persistently infected with HCV will develop liver cirrhosis and hepatocellu lar carcinoma (HCC) [2]. It is estimated that there are 10,000 deaths in the USA per year due to chronic liver failure or HCC [3]. In addition, HCV dis 25-50% of all liver transplants in US centers, and the ease is responsible for recurrence of HCV infection following liver transplantation is universal [4]. Typically, HCV disease emerges after a 10-20 year period during which symp toms, if they exist at all, are mild and non-specific. Although the prevalence varies greatly among different countries, it has been estimated that up to 170 million people (3% of the world's population), are infected with HCV [5]. A recent study in the USA found that 65% of all HCV-infected persons are 30 to 49 years old [6].
European Agricultural Research in the 21st Century
Jointly published with INRA, Paris. What will people eat in the future and how can the food requirements in terms of quantity and quality be met? This EU-based study elucidates the need for a productivity level that will make agriculture competitive on the market and yet is reconciled with the need to manage natural resources and lands wisely. In this book the necessary changes for European agriculture from the biological, medical, economic and political perspective are discussed.
The Alkaloids: Chemistry and Pharmacology
The Alkaloids: Chemistry and Pharmacology
An Introduction to Drug Design
The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.
