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Targeting the Broadly Pathogenic Kynurenine Pathway
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in...
Handbook of Advanced Ceramics
This new handbook will be an essential resource for ceramicists. It includes contributions from leading researchers around the world and includes sections on Basic Science of Advanced Ceramics, Functional Ceramics (electro-ceramics and optoelectro-ceramics) and engineering ceramics. - Contributions from more than 50 leading researchers from around the world - Covers basic science of advanced ceramics, functional ceramics (electro-ceramics and optoelectro-ceramics), and engineering ceramics - Approximately 750 illustrations
Crystal Dislocations: Their Impact on Physical Properties of Crystals
This book is a printed edition of the Special Issue "Crystal Dislocations: Their Impact on Physical Properties of Crystals" that was published in Crystals
3+1 Formalism in General Relativity
This graduate-level, course-based text is devoted to the 3+1 formalism of general relativity, which also constitutes the theoretical foundations of numerical relativity. The book starts by establishing the mathematical background (differential geometry, hypersurfaces embedded in space-time, foliation of space-time by a family of space-like hypersurfaces), and then turns to the 3+1 decomposition of the Einstein equations, giving rise to the Cauchy problem with constraints, which constitutes the core of 3+1 formalism. The ADM Hamiltonian formulation of general relativity is also introduced at this stage. Finally, the decomposition of the matter and electromagnetic field equations is presented,...
Nutritional Oncology
Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of cancer patients, and the risk of cancer recurrence in the rapidly increasing population of cancer survivors.Since the first edition of this book was published in 1999, the idea that there is a single gene pathway or single drug will provide a cure for cancer has given way to the general view that dietary/environmental fac...
Index Medicus
None
Organic Reactions, Volume 91
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.
Catalytic Asymmetric Synthesis
From the reviews of the First Edition . . . "An excellent text . . . will no doubt provide the benchmark for comparative works for many years."-Journal of the American Chemical Society "A resounding success . . . the definitive current summaries on their respective subjects."-Synthesis Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields-from medicine to materials science. Catalytic Asymmetric Synthesis, Second Edition addresses these rapid changes through new or substantially revi...
Sika Deer
Sika deer, the graceful spotted deer of Japanese and Chinese art, originally were native to Asia from far-east Russia to Vietnam to the islands of Japan and Taiwan. They are widely raised in captivity to supply velvet antler for traditional medicine. They also were introduced to Europe, North America, and New Zealand, where they compete or interbreed with native deer. Sika deer typically occupy lowland hardwood forests with low winter snow depths, where they thrive in sites disturbed by fire, storm, or logging. In high numbers they can severely impact vegetation though overgrazing, stripping bark from trees and damaging crop fields and forest plantations. Their numbers are high in many parts of Japan, moderate in Russia, and reduced or extinct in the wild in China, Korea, Vietnam, and Taiwan. This book explores their basic biology, behavior, and ecology, including management for sport hunting, conservation or recovery of threatened populations, and resolution of conflict with humans in native and introduced lands.
